Viral-mediated expression of c-Myc and cyclin A2 induces cochlear progenitor cell proliferation
Viral-mediated expression of c-Myc and cyclin A2 induces cochlear progenitor cell proliferation
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病毒介导的 c-Myc 和细胞周期蛋白 A2 表达诱导耳蜗祖细胞增殖
DOI：
10.1016/j.neulet.2015.02.027
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发表时间：
2015-03
影响因子：
2.5
通讯作者：
Qiu, Jianhua
中科院分区：
文献类型：
--
作者：
Han, Yu;Ma, Ji;Zhang, Xuan;Sun, Mengning;Wang, Ye;Chen, Jun;Mi, Wenjuan;Xu, Xuehai;Qiu, Jianhua
Cochlear progenitor cells have a limited proliferative capability, which prevents their application in treating sensorineural hearing loss. In this study, we showed that the expression of c-Myc and cyclin A2 was down-regulated during the development of cochlear tissue and CPC differentiation. Over-expression of these two genes using adenovirus transduction, significantly affected the CPC cell cycle and promoted the CPC proliferation. We further demonstrated that this promotion involves the classic CKI-cyclin-CDK pathway. Our study suggests that genetically modified CPCs may be a promising cell source for cochlear stem cell transplantation that improves the efficacy of cell therapy.
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影响因子：
82.9
作者：
Kevin Da Silva
通讯作者：
Kevin Da Silva
影响因子：
3.7
作者：
Burns JC;Yoo JJ;Atala A;Jackson JD
通讯作者：
Jackson JD
影响因子：
25
作者：
Zheng, JL;Gao, WQ
通讯作者：
Gao, WQ
影响因子：
7.3
作者：
T. Schimmang;U. Pirvola
通讯作者：
T. Schimmang;U. Pirvola
影响因子：
5.2
作者：
Zhou, Wenbo;Freed, Curt R.
通讯作者：
Freed, Curt R.