The role of ear stone size in hair cell acoustic sensory transduction.
The role of ear stone size in hair cell acoustic sensory transduction.
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DOI：
10.1038/srep02114
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发表时间：
2013
影响因子：
4.6
通讯作者：
Oda, Yoichi
中科院分区：
文献类型：
--
作者：
Inoue, Maya;Tanimoto, Masashi;Oda, Yoichi
听觉和身体平衡是由共同机制引发的不同感觉。声音和头部运动依赖的机械位移都被感觉毛细胞转化为电信号。球囊和椭圆囊内耳器官，结合其中枢投射到后脑，被认为是必不可少的鱼类分离听觉和前庭刺激。在这里，我们建立了一个在体内的方法在幼斑马鱼操纵耳石的生长。我们发现，球囊包含一个大的耳石是必要的，而椭圆囊包含一个小的耳石是不够的。耳石去除和搬迁改变耳石的增长，使实验扩大耳石的椭圆囊获得的声音的感觉。这些结果表明，耳石生物矿化发生在特定区域的方式，并建议，耳石大小的调节在幼斑马鱼耳朵是至关重要的差异感听觉和前庭信息。
Hearing and bodily balance are different sensations initiated by a common mechanism. Both sound- and head movement-dependent mechanical displacement are converted into electrical signals by the sensory hair cells. The saccule and utricle inner ear organs, in combination with their central projections to the hindbrain, are considered essential in fish for separating auditory and vestibular stimuli. Here, we established an in vivo method in larval zebrafish to manipulate otolith growth. We found that the saccule containing a large otolith is necessary to detect sound, whereas the utricle containing a small otolith is not sufficient. Otolith removal and relocation altered otolith growth such that utricles with experimentally enlarged otoliths acquired the sense of sound. These results show that otolith biomineralization occurs in a region-specific manner, and suggest that regulation of otolith size in the larval zebrafish ear is crucial to differentially sense auditory and vestibular information.
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影响因子：
2.8
作者：
Lychakov, DV;Rebane, YT
通讯作者：
Rebane, YT
影响因子：
4.6
作者：
Hammond, Katherine L.;Whitfield, Tanya T.
通讯作者：
Whitfield, Tanya T.
影响因子：
2.9
作者：
Lundberg, Yunxia Wang;Zhao, Xing;Yamoah, Ebenezer N.
通讯作者：
Yamoah, Ebenezer N.
DOI：
10.1111/j.1749-6632.1999.tb09171.x
发表时间：
1999-01-01
期刊：
OTOLITH FUNCTION IN SPATIAL ORIENTATION AND MOVEMENT
影响因子：
--
作者：
Suwa, H;Gilland, E;Baker, R
通讯作者：
Baker, R
影响因子：
2.5
作者：
Tomchik, SM;Lu, ZM
通讯作者：
Lu, ZM