Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of rapamycin in rat hippocampus and prefrontal cortex.
Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of rapamycin in rat hippocampus and prefrontal cortex.
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DOI：
10.1155/2012/175619
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发表时间：
2012
影响因子：
--
通讯作者：
Yang JJ
中科院分区：
文献类型：
--
作者：
Yang C;Li WY;Yu HY;Gao ZQ;Liu XL;Zhou ZQ;Yang JJ
一些证据表明，氯胺酮的急性服用会产生快速的抗抑郁作用。此外，曲马多也有潜在的抗抑郁作用。本研究旨在探讨曲马多预处理对氯胺酮诱导的抗抑郁活性的影响，并测定哺乳动物雷帕霉素靶蛋白（mTOR）在大鼠海马和前额叶皮层的表达。大鼠在第二次强迫游泳试验（FST）前1 h腹腔注射氯胺酮（10mg /kg）或生理盐水。曲马多或生理盐水在前一次给药氯胺酮或生理盐水前30分钟腹腔预处理。测量大鼠FST的运动活动和静止时间。然后处死大鼠，测定海马和前额皮质mTOR的表达。单独给药5mg /kg曲马多不产生抗抑郁作用。更重要的是，曲马多预处理增强了氯胺酮诱导的抗抑郁作用，上调了大鼠海马和前额叶皮层mTOR的表达。曲马多预处理可增强氯胺酮诱导的抗抑郁作用，其机制与大鼠海马和前额皮质mTOR表达增加有关。
Several lines of evidence have demonstrated that acute administration of ketamine elicits fast-acting antidepressant effects. Moreover, tramadol also has potential antidepressant effects. The aim of this study was to investigate the effects of pretreatment with tramadol on ketamine-induced antidepressant activity and was to determine the expression of mammalian target of rapamycin (mTOR) in rat hippocampus and prefrontal cortex. Rats were intraperitoneally administrated with ketamine at the dose of 10 mg/kg or saline 1 h before the second episode of the forced swimming test (FST). Tramadol or saline was intraperitoneally pretreated 30 min before the former administration of ketamine or saline. The locomotor activity and the immobility time of FST were both measured. After that, rats were sacrificed to determine the expression of mTOR in hippocampus and prefrontal cortex. Tramadol at the dose of 5 mg/kg administrated alone did not elicit the antidepressant effects. More importantly, pretreatment with tramadol enhanced the ketamine-induced antidepressant effects and upregulated the expression of mTOR in rat hippocampus and prefrontal cortex. Pretreatment with tramadol enhances the ketamine-induced antidepressant effects, which is associated with the increased expression of mTOR in rat hippocampus and prefrontal cortex.
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DOI：
10.1126/science.1190287
发表时间：
2010-08-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li N;Lee B;Liu RJ;Banasr M;Dwyer JM;Iwata M;Li XY;Aghajanian G;Duman RS
通讯作者：
Duman RS
影响因子：
10.6
作者：
aan het Rot, Marije;Collins, Katherine A.;Mathew, Sanjay J.
通讯作者：
Mathew, Sanjay J.
DOI：
10.4088/jcp.09m05327blu
发表时间：
2010-12
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
DiazGranados N;Ibrahim LA;Brutsche NE;Ameli R;Henter ID;Luckenbaugh DA;Machado-Vieira R;Zarate CA Jr
通讯作者：
Zarate CA Jr
影响因子：
5.3
作者：
de Lima, MNM;Laranja, DC;Schröder, N
通讯作者：
Schröder, N
影响因子：
2.3
作者：
Detke, MJ;Johnson, J;Lucki, I
通讯作者：
Lucki, I