Red cell distribution width is a predictor of all-cause mortality in hospitalized dogs.
Red cell distribution width is a predictor of all-cause mortality in hospitalized dogs.
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DOI：
10.1111/vec.13109
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发表时间：
2022-01
影响因子：
1.3
通讯作者：
Friedenberg, Steven G.
中科院分区：
文献类型：
--
作者：
Ludwik, Tasia M.;Heinrich, Daniel A.;Rendahl, Aaron;Friedenberg, Steven G.
确定红细胞分布宽度（RDW）是否与住院犬猫的死亡几率增加有关。
回顾性单中心研究；数据收集于2007年至2017年。
大学教学医院。
6661只动物（5183只犬和1478只猫）。
无。
从送往急诊且入住重症监护病房（ICU）的动物中确定病历，这些动物在入院时进行了全血细胞计数（CBC）和血清生化检查。根据入院时的RDW将患者分为五组，并进行逻辑回归建模以评估RDW与住院死亡率之间的关系。入院时RDW处于第四和第五五分位数较高位置的犬类患者全因住院死亡的几率增加（P < 0.0001）。具体而言，处于第五五分位数最高位置的犬与处于第一五分位数的犬相比，死亡几率高2.1倍，处于第四五分位数较高位置的犬与处于第一五分位数的犬相比，死亡几率高1.9倍。在对年龄、性别、除血细胞比容（HCT）外的关键实验室指标、内科疾病与外科疾病以及诊断类别进行调整后，这种关系仍然显著。当纳入HCT时，这种关系不再显著。在猫中，未发现入院时RDW与住院死亡率之间存在显著关联。
与RDW较低的犬相比，在送往急诊时RDW较高的住院犬全因住院死亡的几率更大。在猫中未发现RDW与死亡率之间存在类似关联。有必要进一步研究以评估该生物标志物对犬特定疾病的有用性，并更好地理解导致犬类患者RDW增加与死亡率之间关联的机制。
To determine whether red blood cell distribution width (RDW) is associated with an increased odds of mortality in hospitalized dogs and cats. Retrospective, single-center study; data collected from 2007 to 2017. University teaching hospital. Six thousand six hundred and sixty-one animals (5,183 dogs and 1,478 cats). None. Medical records were identified from animals presented to the emergency service and admitted to the ICU with a CBC and serum biochemistry performed on admission. Patients were stratified into quintiles based upon presenting RDW, and logistic regression modeling was performed to evaluate the relationship between RDW and in-hospital mortality. Canine patients with a presenting RDW in the upper fourth and fifth quintiles had an increased odds of all-cause in-hospital mortality (P < 0.0001). Specifically, dogs in the upper fifth quintile had a 2.1-fold greater odds of death compared to dogs in the first quintile, and dogs in the upper fourth quintile had a 1.9-fold greater odds of death compared to dogs in the first quintile. This relationship remained significant after adjusting for age, sex, key laboratory values excluding HCT, medical vs surgical disease, and diagnosis category. This relationship was no longer significant with the inclusion of HCT. No significant association was identified between presenting RDW and in-hospital mortality in cats. Hospitalized dogs with higher RDW on presentation to the emergency service have greater odds of all-cause in-hospital mortality compared to dogs with a lower RDW. A similar association between RDW and mortality was not found in cats. Further studies are warranted to assess the usefulness of this biomarker for specific diseases in dogs and to better understand the mechanisms driving the association between increased RDW and mortality in canine patients.
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影响因子：
4.1
作者：
Laftah, Abas H.;Sharma, Naveen;Tselepis, Chris
通讯作者：
Tselepis, Chris
影响因子：
1.1
作者：
Marchetti, V.;Gori, E.;Pierini, A.
通讯作者：
Pierini, A.
重症患者的红细胞分布宽度和全因死亡率。
影响因子：
8.8
作者：
Bazick HS;Chang D;Mahadevappa K;Gibbons FK;Christopher KB
通讯作者：
Christopher KB
影响因子：
1.2
作者：
Boisvert, AM;Tvedten, HW;Scott, MA
通讯作者：
Scott, MA
影响因子：
2.8
作者：
Fujita, Buntaro;Franz, Marcus;Jung, Christian
通讯作者：
Jung, Christian