Effect of a fifth round of seasonal malaria chemoprevention in children aged 5-14 years in Dangassa, an area of long transmission in Mali.
Effect of a fifth round of seasonal malaria chemoprevention in children aged 5-14 years in Dangassa, an area of long transmission in Mali.
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DOI：
10.1016/j.parepi.2022.e00283
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发表时间：
2023-02
影响因子：
3.2
通讯作者：
Diakite, Mahamadou
中科院分区：
文献类型：
--
作者：
Konate, Drissa;Diawara, Sory I.;Sogoba, Nafomon;Shaffer, Jeff;Keita, Bourama;Cisse, Abdourhamane;Sanogo, Ibrahim;Dicko, Ilo;Guindo, Merepen dite Agnes;Balam, Saidou;Traore, Abdouramane;Kante, Salimata;Dembele, Assitan;Kasse, Fatoumata;Denou, Larissa;Diakite, Seidina A. S.;Traore, Karim;Thiam, Sidibe M'Baye;Sanogo, Vincent;Toure, Mahamoudou;Diarra, Ayouba;Agak, George W.;Doumbia, Seydou;Diakite, Mahamadou
尽管五岁以下儿童的疟疾负担显着减轻，但大规模有效实施季节性疟疾化学预防（SMC）仍然是疟疾长期传播地区的一个主要问题。雨季难以到达的地区覆盖率低、疟疾风险向年龄较大儿童转移、停药后疟疾发病率反弹等现象主要集中在这些地区。这些差距对有效实施 SMC 措施构成了重大挑战。进行了一项开放随机研究，以评估在当前 SMC 方案的基础上增加第五轮对居住在农村疟疾流行区 Dangassa 的年龄较大儿童的影响。使用泊松回归模型来估计干预组与对照组（包括年龄组（5-9 岁和 10-14 岁）和使用长效杀虫蚊帐（LLIN；是或否））相比疟疾发病率的降低情况，阈值为 5%。总体而言，从8月（94.3%）到11月（87.2%），参与率呈下降趋势。 11 月（第 4 轮），两组的疟疾发病风险相似（IRR = 0.66，95% CI [0.35–1.22]）。 12 月（第 5 轮），与根据年龄组和 LLIN 使用进行调整的对照组相比，干预组的疟疾发病率下降了 51%（IRR = 0.49，95% CI [0.26–0.94]），其中 17% 的下降归因于干预组的第 5 轮。额外的第五轮 SMC 导致干预组的疟疾发病率显着降低。 SMC 轮数可根据当地疟疾传播情况进行调整。
Despite a significant reduction in the burden of malaria in children under five years-old, the efficient implementation of seasonal malaria chemoprevention (SMC) at large scale remains a major concern in areas with long malaria transmission. Low coverage rate in the unattainable areas during the rainy season, a shift in the risk of malaria to older children and the rebound in malaria incidence after stopping drug administration are mainly reported in these areas. These gaps represent a major challenge in the efficient implementation of SMC measures. An open randomized study was conducted to assess the effect of a fifth additional round to current regime of SMC in older children living in Dangassa, a rural malaria endemic area. Poisson regression Model was used to estimate the reduction in malaria incidence in the intervention group compared to the control group including age groups (5–9 and 10–14 years) and the use of long-lasting insecticidal nets (LLINs; Yes or No) with a threshold at 5%. Overall, a downward trend in participation rate was observed from August (94.3%) to November (87.2%). In November (round 4), the risk of malaria incidence was similar in both groups (IRR = 0.66, 95%CI [0.35–1.22]). In December (round 5), a decrease of 51% in malaria incidence was observed in intervention group compared to control group adjusted for age groups and the use of LLINs (IRR = 0.49, 95%CI [0.26–0.94]), of which 17% of reduction is attributable to the 5th round in the intervention group. An additional fifth round of SMC resulted in a significant reduction of malaria incidence in the intervention group. The number of SMC rounds could be adapted to the local condition of malaria transmission.
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DOI：
10.1016/s0140-6736(20)32227-3
发表时间：
2020-12-05
期刊：
Lancet (London, England)
影响因子：
--
作者：
ACCESS-SMC Partnership
通讯作者：
ACCESS-SMC Partnership
影响因子：
3.2
作者：
Pitt, Catherine;Ndiaye, Mouhamed;Milligan, Paul J.
通讯作者：
Milligan, Paul J.
影响因子：
3
作者：
Konate, Drissa;Diawara, Sory, I;Diakite, Mahamadou
通讯作者：
Diakite, Mahamadou
影响因子：
8.1
作者：
Njunda, Anna Longdoh;Fon, Shuri Ghasarah;Kwenti, Tebit Emmanuel
通讯作者：
Kwenti, Tebit Emmanuel
在马里塞林格湖附近的Binko和Carrière村庄的季节性和特定年龄的疟疾患病率和发病率的转变。
影响因子：
3
作者：
Touré M;Sanogo D;Dembele S;Diawara SI;Oppfeldt K;Schiøler KL;Haidara DB;Traoré SF;Alifrangis M;Konradsen F;Doumbia S
通讯作者：
Doumbia S