Homocysteine and cognitive function in Parkinson's disease.
Homocysteine and cognitive function in Parkinson's disease.
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DOI：
10.1016/j.parkreldis.2017.08.005
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发表时间：
2017-11
影响因子：
4.1
通讯作者：
Quinn JF
中科院分区：
文献类型：
--
作者：
Licking N;Murchison C;Cholerton B;Zabetian CP;Hu SC;Montine TJ;Peterson-Hiller AL;Chung KA;Edwards K;Leverenz JB;Quinn JF
血浆同型半胱氨酸（HC）升高是一般人群患痴呆症的危险因素。左旋多巴治疗会导致血浆 HC 升高，但尚不清楚血浆 HC 升高是否与帕金森病 (PD) 认知障碍有关。研究人群包括研究时太平洋西北尤德尔中心 (PANUC) 临床队列的所有参与者，其中包括 294 名患有 PD 的患者，他们接受了标准化的神经心理学评估并采集了用于 HC 测量的血浆。我们检验了以下假设：血浆 HC 升高与 PD 患者的认知功能呈负相关。正如预期的那样，血浆 HC 与年龄、病程、疾病严重程度和左旋多巴使用呈正相关，而认知功能与年龄、教育程度、性别和 APOE 基因型相关，因此后续分析控制了这些协变量。当血浆HC分为正常（<14μmol/L）或升高（≥14μmol/L）时，高同型半胱氨酸血症受试者在数字符号（p=0.031）、霍普金斯语言学习任务（HVLT）延迟回忆（p=0.004）和语义语言流畅性（p=0.049）方面得分较低。当作为连续变量进行检查时，血浆 HC 与 HVLT 延迟回忆 (p=0.009)) 和语义语言流畅性 (p=0.004) 呈负相关，但与数字符号、路径制作测试、线路方向判断、音素语言流畅性、MMSE 或 MOCA 没有显着相关。当分析仅限于非痴呆受试者 (n=231) 时，结果没有变化。我们的结论是，血浆 HC 与 PD 认知功能的某些方面显着相关，并且可能代表 PD 认知功能下降的可治疗危险因素。
Increased plasma homocysteine (HC) is a risk factor for dementia in the general population. Levodopa therapy causes increased plasma HC, but it remains unclear whether elevated plasma HC is associated with cognitive impairment in Parkinson’s disease (PD). The study population includes all participants in the Pacific Northwest Udall Center (PANUC) Clinical cohort at the time of the study, consisting of 294 individuals with PD who had a standardized neuropsychological assessment and plasma collection for HC measurement. We tested the hypothesis that elevated plasma HC is inversely related to cognitive function in patients with PD. As expected, plasma HC was positively associated with age, disease duration, disease severity, and levodopa usage, while cognitive function was associated with age, education, gender, and APOE genotype, so subsequent analyses controlled for these covariates. When plasma HC was dichotomized as normal (<14 μmol/L) or elevated (≥14 μmol/L), subjects with hyper-homocysteinemia had lower scores on Digit Symbol (p=0.031), Hopkins Verbal Learning Task (HVLT) Delayed Recall (p=0.004), and semantic verbal fluency (p=0.049). When examined as a continuous variable, plasma HC was inversely associated with HVLT Delayed Recall (p=0.009)) and semantic verbal fluency (p=0.004), but was not significantly related to Digit symbol, Trail-making test, Judgment of Line Orientation, phonemic verbal fluency, MMSE, or MOCA. When analysis was restricted to non-demented subjects (n=231), the findings were unchanged. We conclude that plasma HC is significantly associated with some aspects of cognitive function in PD, and may represent a treatable risk factor for cognitive decline in PD.
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DOI：
10.3233/jpd-130189
发表时间：
2013
期刊：
Journal of Parkinson's disease
影响因子：
--
作者：
Cholerton BA;Zabetian CP;Quinn JF;Chung KA;Peterson A;Espay AJ;Revilla FJ;Devoto J;Watson GS;Hu SC;Edwards KL;Montine TJ;Leverenz JB
通讯作者：
Leverenz JB
影响因子：
8.6
作者：
Goldman, Jennifer G.;Holden, Samantha;Ouyang, Bichun;Bernard, Bryan;Goetz, Christopher G.;Stebbins, Glenn T.
通讯作者：
Stebbins, Glenn T.
DOI：
10.1002/mds.26359
发表时间：
2016-01
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Mata IF;Leverenz JB;Weintraub D;Trojanowski JQ;Chen-Plotkin A;Van Deerlin VM;Ritz B;Rausch R;Factor SA;Wood-Siverio C;Quinn JF;Chung KA;Peterson-Hiller AL;Goldman JG;Stebbins GT;Bernard B;Espay AJ;Revilla FJ;Devoto J;Rosenthal LS;Dawson TM;Albert MS;Tsuang D;Huston H;Yearout D;Hu SC;Cholerton BA;Montine TJ;Edwards KL;Zabetian CP
通讯作者：
Zabetian CP
影响因子：
4
作者：
Song, In-Uk;Kim, Joong-Seok;Lee, Kwang-Soo
通讯作者：
Lee, Kwang-Soo
影响因子：
29
作者：
Mata, Ignacio F.;Leverenz, James B.;Weintraub, Daniel;Trojanowski, John Q.;Hurtig, Howard I.;Van Deerlin, Vivianna M.;Ritz, Beate;Rausch, Rebecca;Rhodes, Shannon L.;Factor, Stewart A.;Wood-Siverio, Cathy;Quinn, Joseph F.;Chung, Kathryn A.;Peterson, Amie L.;Espay, Alberto J.;Revilla, Fredy J.;Devoto, Johnna;Hu, Shu-Ching;Cholerton, Brenna A.;Wan, Jia Y.;Montine, Thomas J.;Edwards, Karen L.;Zabetian, Cyrus P.
通讯作者：
Zabetian, Cyrus P.