Alteration of frontal EEG asymmetry during tryptophan depletion predicts future depression.
Alteration of frontal EEG asymmetry during tryptophan depletion predicts future depression.
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DOI：
10.1016/j.jad.2008.08.003
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发表时间：
2009-05
影响因子：
6.6
通讯作者：
Delgado, Pedro L.
中科院分区：
文献类型：
--
作者：
Allen, John J. B.;McKnight, Katherine M.;Moreno, Francisco A.;Demaree, Heath A.;Delgado, Pedro L.
色氨酸耗竭（TD）会降低脑5-羟色胺，并可能诱发急性抑郁症，尤其是在有重度抑郁症病史的患者中。在有抑郁症病史的心境正常患者中，对TD的抑郁反应也预示着未来的抑郁症。在TD的背景下，通过评估抑郁风险的假定内表型，额叶脑电图（EEG）不对称性，可能会得到更好的预测。9名正常胸腺史阳性的参与者和9名对照者接受TD给药。TD后6小时收集症状和EEG额叶不对称数据，并在接下来的12个月内随访临床状态。TD引起的额叶脑电图不对称性变化的幅度显着预测抑郁症的发展，在随后的6至12个月，并具有更大的灵敏度比症状反应。由于样本量小，结果有所缓和。尽管样本量有限，这些初步结果表明，TD引起的额叶脑电图不对称性的变化可能提供了一个更敏感的指标，比症状性反应TD的风险迫在眉睫的抑郁症。
Tryptophan depletion (TD) reduces brain serotonin and may induce acute depressive symptomatology, especially among those with a history of Major Depression. Depressive response to TD among euthymic patients with a history of depression also predicts future depression. Better prediction might result by assessing a putative endophenotype for depressive risk, frontal electroencephalographic (EEG) asymmetry, in the context of TD. Nine euthymic history-positive participants and nine controls were administered TD. Symptomatic and EEG frontal asymmetry data were collected for 6 hours following TD, and clinical status was followed for the next 12 months. The magnitude of TD-induced change in frontal EEG asymmetry significantly predicted the development of depression during the ensuing six to twelve months, and with greater sensitivity than symptomatic response. The results are tempered by the small sample size. Despite the limited sample size, these preliminary results suggest that TD-induced changes in frontal EEG asymmetry may provide a more sensitive indicator of risk for imminent depression than symptomatic response to TD.
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