The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity.
The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity.
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ANGPTL8 对 HDL 介导的胆固醇流出能力的负面影响
DOI：
10.1186/s12933-018-0785-x
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发表时间：
2018-11-08
影响因子：
9.3
通讯作者：
Peng D
中科院分区：
文献类型：
--
作者：
Luo M;Zhang Z;Peng Y;Wang S;Peng D
背景血管生成素样蛋白8（angiopoietin-like protein 8，ANGPTL 8）通过抑制脂蛋白脂酶和升高血浆甘油三酯而影响脂质代谢。然而，目前尚不清楚ANGPTL 8是否可以通过其他途径影响脂质代谢。本研究旨在探讨ANGPTL 8对高密度脂蛋白（HDL）功能的影响，HDL在动脉粥样硬化进展中起着保护作用。通过酶联免疫吸附测定法测定血浆ANGPTL 8。结果冠心病组与非冠心病组ANGPTL 8无显著性差异，但糖尿病组ANGPTL 8显著高于非糖尿病组[568. 3（406.2-836.8）vs 458.2（356.8-755.6），P = 0.023]。与对照组相比，冠心病组和糖尿病组的胆固醇外排能力均显著降低[冠心病组：14.58 ± 2.06vs12.51 ± 2.83%，P < 0.0001;糖尿病组：13.62 ± 2.57vs12.34 ± 3.16%，P = 0.0099]。ANGPTL 8与胆固醇外排能力呈负相关（r =-0.188，P < 0.01）。回归分析显示，血浆ANGPTL 8对HDL介导的胆固醇外排能力有独立影响（标准化β =-0.143，P = 0.023）。
BackgroundIt is well known that angiopoietin-like protein 8 (ANGPTL8) exerts its effects on lipid metabolism through the inhibition of lipoprotein lipase and subsequent elevation of plasma triglyceride. However, it is not clear whether ANGPTL8 could affect lipid metabolism via other pathways. The study was aimed to investigate the effects of ANGPTL8 on the function of high-density lipoprotein (HDL), which plays a protective role in atherosclerosis progression.MethodsTwo hundred and ten subjects were recruited. Plasma ANGPTL8 was measured by enzyme-linked immunosorbent assays. Cholesterol efflux capacity was chosen as the biomarker of HDL function and measured via H3-cholesterol loading THP-1 cell models.ResultsANGPTL8 exhibited no significant difference between CAD group and nonCAD group, but ANGPTL8 in DM group was significantly higher than that in the nonDM group [568.3 (406.2–836.8) vs 458.2 (356.8–755.6), P = 0.023]. Compared to controls, subjects in CAD group and DM group exhibited significantly lower cholesterol efflux capacity [CAD: 14.58 ± 2.06 vs 12.51 ± 2.83%, P < 0.0001; DM: 13.62 ± 2.57 vs 12.34 ± 3.16%, P = 0.0099]. ANGPTL8 was inversely correlated with cholesterol efflux capacity (r = − 0.188, P < 0.01). Regression analysis revealed that plasma ANGPTL8 was an independent contributor to cholesterol efflux capacity (standardized β = − 0.143, P = 0.023).ConclusionANGPTL8 presents a negative effect on HDL-mediated cholesterol efflux capacity.
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影响因子：
9.3
作者：
Chen CC;Susanto H;Chuang WH;Liu TY;Wang CH
通讯作者：
Wang CH
炎症，重塑和其他影响HDL胆固醇外排的因素。
影响因子：
4.4
作者：
Ronsein GE;Vaisar T
通讯作者：
Vaisar T
影响因子：
105.7
作者：
Keene, Daniel;Price, Clare;Francis, Darrel P.
通讯作者：
Francis, Darrel P.
DOI：
10.1073/pnas.1217552109
发表时间：
2012-11-27
影响因子：
11.1
作者：
Quagliarini, Fabiana;Wang, Yan;Hobbs, Helen H.
通讯作者：
Hobbs, Helen H.
DOI：
10.1161/atvbaha.113.301373
发表时间：
2013-07
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Li XM;Tang WH;Mosior MK;Huang Y;Wu Y;Matter W;Gao V;Schmitt D;Didonato JA;Fisher EA;Smith JD;Hazen SL
通讯作者：
Hazen SL