Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors.
Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors.
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DOI：
10.1038/s41523-022-00396-z
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发表时间：
2022-03-07
影响因子：
5.9
通讯作者：
Irwin ML
中科院分区：
文献类型：
--
作者：
Dieli-Conwright CM;Harrigan M;Cartmel B;Chagpar A;Bai Y;Li FY;Rimm DL;Pusztai L;Lu L;Sanft T;Irwin ML
很少有试验研究生活方式行为干预对癌症患者组织标志物的影响。本研究的目的是检查6个月的减肥干预对乳腺癌妇女乳腺组织和血清生物标志物的可行性和影响。51名完成乳腺癌治疗且BMI ≥ 25.0 kg/m2的女性随机接受减肥干预或常规护理。在基线和6个月时收集乳腺组织活检、空腹抽血和身体成分，使用协方差分析方法检查组间变化。分别在49名和42名妇女中进行了基线和干预后活检，从25个组织样本中获得了前上皮组织和后上皮组织。减肥组6个月平均体重减轻6.7%，常规护理组增加2.0%（p < 0.0001）。基线时，体脂和血清胰岛素水平与乳腺组织胰岛素受体水平和CD 68呈负相关（p < 0.05）。在6个月时，在随机分配到体重减轻组的妇女中观察到血清瘦素和脂联素水平以及组织CD 163的有利变化，而在随机分配到常规护理组的妇女中观察到不利变化（p < 0.05）。在临床研究环境中，在乳腺癌幸存者中收集乳腺组织活检是可行的，体重减轻对与乳腺癌相关的代谢和炎症标志物产生了有利的影响。
Few trials have examined the effect of lifestyle behavioral interventions on tissue markers in patients with cancer. The purpose of this study was to examine the feasibility and impact of a 6-month weight loss intervention on breast tissue and serum biomarkers in women with breast cancer. Fifty-one women who completed breast cancer treatment and had a BMI ≥ 25.0 kg/m2 were randomized to a weight loss intervention or usual care. Breast tissue biopsies, fasting blood draw and body composition were collected at baseline and 6 months, with between-group changes examined using analysis of covariance method. Baseline and post-intervention biopsies were conducted in 49 and 42 women, respectively, with pre- and post-epithelial tissue available from 25 tissue samples. Average 6-month weight loss was 6.7% for the weight loss group and 2.0% increase for the usual care group (p < 0.0001). At baseline, body fat and serum insulin levels were inversely associated with breast tissue insulin receptor levels and CD68 (p < 0.05). At 6 months, favorable changes were observed in serum leptin and adiponectin levels and tissue CD163 among women randomized to weight loss vs. adverse change in women randomized to usual care (p < 0.05). Breast tissue biopsies are feasible to collect in a clinical research setting among breast cancer survivors, with weight loss favorably impacting metabolic and inflammatory markers associated with breast cancer.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
8.8
作者：
Demark-Wahnefried W;Rais-Bahrami S;Desmond RA;Gordetsky JB;Hunter GR;Yang ES;Azrad M;Frugé AD;Tsuruta Y;Norian LA;Segal R;Grizzle WE
通讯作者：
Grizzle WE
影响因子：
3.3
作者：
Campbell, Kristin L.;Foster-Schubert, Karen E.;Ulrich, Cornelia M.
通讯作者：
Ulrich, Cornelia M.
影响因子：
3.8
作者：
McTiernan, Anne;Yasui, Yutaka;Lampe, Paul D.
通讯作者：
Lampe, Paul D.