Bimodal Targeting Using Sulfonated, Mannosylated PEI for Combined Gene Delivery and Photodynamic Therapy.
Bimodal Targeting Using Sulfonated, Mannosylated PEI for Combined Gene Delivery and Photodynamic Therapy.
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DOI：
10.1111/php.12688
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发表时间：
2017-03
影响因子：
3.3
通讯作者：
Lovell JF
中科院分区：
文献类型：
--
作者：
Chitgupi U;Li Y;Chen M;Shao S;Beitelshees M;Tan MJ;Neelamegham S;Pfeifer BA;Jones C;Lovell JF
Photodynamic therapy (PDT) and gene delivery have both been used to target both cancer cells and tumor-associated macrophages (TAMs). Given the complex nature of tumor tissue, there could be merit in combining these strategies simultaneously. In this study, we developed a bimodal targeting approach to both cancer cells and macrophages, employing materials conducive to both gene delivery and PDT. Polymers libraries were created that consisted of cationic polyethyleneimine (PEI) conjugated to the photosensitizer pyropheophorbide-α, with sulfonation (to target selectin-expressing cells) and mannosylation (to target TAMs). Polyplexes, consisting of these polymers electrostatically bound to DNA, were analyzed for transfection efficacy and cytotoxicity towards epithelial cells and macrophages to assess dual-targeting. This study provides preliminary proof of principle for using modified PEI for targeted gene delivery and PDT.
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DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
5.8
作者：
Park, In Young;Kim, In Yong;Cho, Chong Su
通讯作者：
Cho, Chong Su
影响因子：
32.4
作者：
Noy, Roy;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.
影响因子：
4.8
作者：
Diebold, SS;Kursa, P;Zenke, M
通讯作者：
Zenke, M
影响因子：
2.9
作者：
HEMMERICH, S;BERTOZZI, CR;ROSEN, SD
通讯作者：
ROSEN, SD