Longitudinal Plasma Metabolomics Profile in Pregnancy-A Study in an Ethnically Diverse U.S. Pregnancy Cohort.
Longitudinal Plasma Metabolomics Profile in Pregnancy-A Study in an Ethnically Diverse U.S. Pregnancy Cohort.
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妊娠期纵向血浆代谢组学特征：一项在美国不同种族妊娠队列中进行的研究。
DOI：
10.3390/nu13093080
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发表时间：
2021-09-01
期刊：
影响因子：
5.9
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Mitro SD;Wu J;Rahman ML;Cao Y;Zhu Y;Chen Z;Chen L;Li M;Hinkle SN;Bremer AA;Weir NL;Tsai MY;Song Y;Grantz KL;Gelaye B;Zhang C
氨基酸，脂肪酸和酰基肉毒碱代谢产物在母亲和胎儿的健康中起着关键作用，但这些代谢产物在妊娠期间的分布并不完全确定。我们描述了纵向轨迹的目标氨基酸，脂肪酸和酰基肉毒碱在怀孕。我们定量了102种代谢物和组合Eunice Kennedy Shriver国家儿童健康和人类发育研究所（NICHD）胎儿生长发育-单胎队列中孕妇血浆样本中的37种脂肪酸、37种氨基酸和28种酰基肉毒碱（n = 10-14和15-26周时214名女性，26-31周时107名女性，33-39周时103名女性）。我们使用线性混合模型来估计代谢物轨迹，并检查体重指数（BMI），种族/民族和胎儿性别的变化。在排除了大量未检测到的代谢物后，我们分析了77种代谢物和组合。13的15酰基肉毒碱，7的25种氨基酸和18的37种脂肪酸的水平显着下降，而8的25种氨基酸和10的37种脂肪酸显着增加。尽管在多重检验校正后，相互作用的检验仍无显著性，但几种轨迹似乎因BMI、人种/种族和胎儿性别而异。未来的研究值得纵向测量，以捕捉代谢物的变化在怀孕期间，和更大的样本，以检查修改的影响，母亲和胎儿的特点。
Amino acids, fatty acids, and acylcarnitine metabolites play a pivotal role in maternal and fetal health, but profiles of these metabolites over pregnancy are not completely established. We described longitudinal trajectories of targeted amino acids, fatty acids, and acylcarnitines in pregnancy. We quantified 102 metabolites and combinations (37 fatty acids, 37 amino acids, and 28 acylcarnitines) in plasma samples from pregnant women in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies—Singletons cohort (n = 214 women at 10–14 and 15–26 weeks, 107 at 26–31 weeks, and 103 at 33–39 weeks). We used linear mixed models to estimate metabolite trajectories and examined variation by body mass index (BMI), race/ethnicity, and fetal sex. After excluding largely undetected metabolites, we analyzed 77 metabolites and combinations. Levels of 13 of 15 acylcarnitines, 7 of 25 amino acids, and 18 of 37 fatty acids significantly declined over gestation, while 8 of 25 amino acids and 10 of 37 fatty acids significantly increased. Several trajectories appeared to differ by BMI, race/ethnicity, and fetal sex although no tests for interactions remained significant after multiple testing correction. Future studies merit longitudinal measurements to capture metabolite changes in pregnancy, and larger samples to examine modifying effects of maternal and fetal characteristics.
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影响因子：
5.6
作者：
O'Neill K;Alexander J;Azuma R;Xiao R;Snyder NW;Mesaros CA;Blair IA;Pinney SE
通讯作者：
Pinney SE
影响因子：
3.7
作者：
Lindsay KL;Hellmuth C;Uhl O;Buss C;Wadhwa PD;Koletzko B;Entringer S
通讯作者：
Entringer S
影响因子：
6.3
作者：
Lin, Yuan;Wu, Jing;Zhang, Cuilin
通讯作者：
Zhang, Cuilin
影响因子：
7.7
作者：
Grewal, Jagteshwar;Grantz, Katherine L.;Louis, Germaine M. Buck
通讯作者：
Louis, Germaine M. Buck
影响因子：
2.5
作者：
NAKANO, C;TAKASHIMA, S;TAKESHITA, K
通讯作者：
TAKESHITA, K