Meibomian Gland Dysfunction: What Have Animal Models Taught Us?
Meibomian Gland Dysfunction: What Have Animal Models Taught Us?
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DOI：
10.3390/ijms21228822
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发表时间：
2020-11-21
影响因子：
5.6
通讯作者：
Coulson-Thomas VJ
中科院分区：
文献类型：
--
作者：
Sun M;Moreno IY;Dang M;Coulson-Thomas VJ
研究估计，目前全球有3.44亿人和美国1640万成年人患有某种形式的干眼病（DED）。据信，大约70%的DED病例是由于某种形式的蒸发性干眼症引起的，其中睑板腺功能障碍（MGD）是主要原因。不幸的是，目前没有有效的治疗MGD，只有姑息治疗。鉴于MGD在DED中的重要性，人们对研究睑板腺发育、稳态和病理以及开发用于治疗和/或预防MGD的疗法越来越感兴趣。为此，动物模型已被证明是一个重要的工具。今天所知的关于睑板腺和MGD的许多知识都是从这些重要的动物模型中学习的。特别是，犬和兔模型对于研究DED的生理病理学和进展至关重要，并且包括不同敲除菌株的小鼠模型已经能够鉴定可能参与MGD的特定途径。在此，我们提供了一个书目审查的各种动物模型，已被用于研究睑板腺发育，睑板腺稳态和MGD，主要集中在2000年和2020年之间的出版物。
Studies have estimated that currently 344 million people worldwide and 16.4 million adults in the US have some form of dry eye disease (DED). It is believed that approximately 70% of DED cases are due to some form of evaporative dry eye, for which Meibomian gland dysfunction (MGD) is the major cause. Unfortunately, currently there is no effective treatment for MGD, and solely palliative care is available. Given the importance of MGD in DED, there has been a growing interest in studying Meibomian gland development, homeostasis and pathology, and, also, in developing therapies for treating and/or preventing MGD. For such, animal models have shown to be a vital tool. Much of what is known today about the Meibomian gland and MGD was learnt from these important animal models. In particular, canine and rabbit models have been essential for studying the physiopathology and progression of DED, and the mouse model, which includes different knockout strains, has enabled the identification of specific pathways potentially involved in MGD. Herein, we provide a bibliographic review on the various animal models that have been used to study Meibomian gland development, Meibomian gland homeostasis and MGD, primarily focusing on publications between 2000 and 2020.
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影响因子：
4.4
作者：
Arciniega, Juan C.;Uchiyama, Eduardo;Butovich, Igor A.
通讯作者：
Butovich, Igor A.
影响因子：
4.4
作者：
Butovich, Igor A.;Arciniega, Juan C.;Molai, Mike
通讯作者：
Molai, Mike
影响因子：
2.8
作者：
Den, Seika;Shimizu, Kazuhiro;Shimazaki, Jun
通讯作者：
Shimazaki, Jun
DOI：
10.1073/pnas.80.1.283
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BLUE, ML;WILLIAMS, DL;BLUM, CB
通讯作者：
BLUM, CB
影响因子：
4.8
作者：
Cascallana, JL;Bravo, A;Pérez, P
通讯作者：
Pérez, P