Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation.
Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation.
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DOI：
10.1016/j.clinthera.2015.04.002
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发表时间：
2015-05-01
影响因子：
3.2
通讯作者：
Theoharides TC
中科院分区：
文献类型：
--
作者：
Petra AI;Panagiotidou S;Hatziagelaki E;Stewart JM;Conti P;Theoharides TC
肠道微生物群调节肠道功能和健康。然而，越来越多的证据表明，它们也会影响免疫和神经系统，反之亦然。在这里，我们回顾了肠道微生物群和大脑之间的双向关系，称为微生物群-肠道-大脑（MGB）轴，并讨论了它如何促进某些可能涉及大脑炎症的疾病的发病机制。自1980年以来，使用关键词焦虑、注意力缺陷超敏反应障碍（ADHD）、自闭症、细胞因子、抑郁症、肠道、下丘脑-垂体-肾上腺（HPA）轴、炎症、免疫系统、微生物群、神经系统、神经系统、神经递质、神经免疫状况、精神病、压力从Medline中选择文章。各种传入或传出通路参与MGB轴。抗生素、环境和感染因子、肠神经递质/神经调质、感觉迷走神经纤维、细胞因子、必需代谢物都将关于肠状态的信息传递给CNS。相反，HPA轴、饱腹感的CNS调节区域和从感觉神经纤维释放的神经肽直接或通过营养物质的可用性影响肠道微生物群组成。这种相互作用似乎影响许多涉及炎症的疾病的发病机制，例如情绪障碍、自闭症谱系障碍（ASD）、注意力缺陷超敏反应障碍（ADHD）、多发性硬化症（MS）和肥胖症。MGB轴和神经免疫系统之间的关系的认识提供了一种新的方法，更好地理解和管理这些疾病。适当的预防措施在生命早期或纠正措施，如使用精神生物药，粪便微生物移植和黄酮类化合物进行了讨论。
Gut microbiota regulate intestinal function and health. However, mounting evidence indicates that they can also influence the immune and nervous systems and vice versa. Here we reviewed the bidirectional relationship between the gut microbiota and the brain, termed microbiota-gut-brain (MGB) axis, and we discuss how it contributes to the pathogenesis of certain disorders, that may involve brain inflammation. Articles were chosen from Medline since 1980 using the key words anxiety, attention-deficit hypersensitivity disorder (ADHD), autism, cytokines, depression, gut, hypothalamic-pituitary-adrenal (HPA) axis, inflammation, immune system, microbiota, nervous system, neurologic, neurotransmitters, neuroimmune conditions, psychiatric, stress. Various afferent or efferent pathways are involved in the MGB axis. Antibiotics, environmental and infectious agents, intestinal neurotransmitters/neuromodulators, sensory vagal fibers, cytokines, essential metabolites, all convey information about the intestinal state to the CNS. Conversely, the HPA axis, the CNS regulatory areas of satiety and neuropeptides released from sensory nerve fibers affect the gut microbiota composition directly or through nutrient availability. Such interactions appear to influence the pathogenesis of a number of disorders in which inflammation is implicated such as mood disorder, autism-spectrum disorders (ASDs), attention-deficit hypersensitivity disorder (ADHD), multiple sclerosis (MS) and obesity. Recognition of the relationship between the MGB axis and the neuroimmune systems provides a novel approach for better understanding and management of these disorders. Appropriate preventive measures early in life or corrective measures such as use of psychobiotics, fecal microbiota transplantation and flavonoids are discussed.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
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影响因子：
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影响因子：
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作者：
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通讯作者：
Theoharides, TC
影响因子：
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通讯作者：
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