Genetically and environmentally predicted obesity in relation to cardiovascular disease: a nationwide cohort study.
Genetically and environmentally predicted obesity in relation to cardiovascular disease: a nationwide cohort study.
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DOI：
10.1016/j.eclinm.2023.101943
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发表时间：
2023-04
影响因子：
15.1
通讯作者：
Karlsson, Ida K.
中科院分区：
文献类型：
--
作者：
Ojalehto, Elsa;Zhan, Yiqiang;Jylhava, Juulia;Reynolds, Chandra A.;Aslan, Anna K. Dahl;Karlsson, Ida K.
有证据表明，肥胖对健康的不良影响在遗传和环境影响的肥胖之间是不同的。我们研究了肥胖和心血管疾病（CVD）之间的差异之间的关联与遗传预测的低，中，高体重指数（BMI）的个人。我们使用了1959年之前出生的瑞典双胞胎的队列数据，这些双胞胎的BMI测量年龄在40-64岁（中年）或65岁或以上（晚年），或两者兼而有之，以及截至2016年的全国登记连锁的前瞻性CVD信息。BMI的多基因评分（PGSBMI）用于定义遗传预测的BMI。缺失BMI或协变量数据的个体，或在第一次BMI测量时诊断为CVD的个体被排除在外，留下17，988人的分析样本。我们应用考克斯比例风险模型来检验BMI类别与CVD事件之间的关联，并按PGSBMI分层。共双胞胎控制模型，以调整遗传影响没有捕获的PGSBMI。在1984年至2010年期间，17，988名参与者参加了瑞典双胞胎登记处的子研究。在所有PGSBMI类别中，中年肥胖与CVD风险较高相关，但与遗传预测的较低BMI相关性更强（高和低PGSBMI患者的风险比分别为1.55至2.08）。在同卵双胞胎中，遗传预测的BMI没有差异，表明遗传混杂没有被PGSBMI捕获。当在晚年测量肥胖时，结果是相似的，但受到低功率的影响。无论PGSBMI类别如何，肥胖与CVD相关，但受遗传易感性影响的肥胖（遗传预测的高BMI）比受环境因素影响的肥胖（尽管遗传预测的低BMI肥胖）危害小。然而，PGSBMI未捕获的其他遗传因素仍会影响相关性。;;
Evidence indicates that the adverse health effects of obesity differ between genetically and environmentally influenced obesity. We examined differences in the association between obesity and cardiovascular disease (CVD) between individuals with a genetically predicted low, medium, or high body mass index (BMI). We used cohort data from Swedish twins born before 1959 who had BMI measured between the ages of 40–64 years (midlife) or at the age of 65 years or later (late-life), or both, and prospective CVD information from nationwide register linkage through 2016. A polygenic score for BMI (PGSBMI) was used to define genetically predicted BMI. Individuals missing BMI or covariate data, or diagnosed with CVD at first BMI measure, were excluded, leaving an analysis sample of 17,988 individuals. We applied Cox proportional hazard models to examine the association between BMI category and incident CVD, stratified by the PGSBMI. Co-twin control models were applied to adjust for genetic influences not captured by the PGSBMI. Between 1984 and 2010, the 17,988 participants were enrolled in sub-studies of the Swedish Twin Registry. Midlife obesity was associated with a higher risk of CVD across all PGSBMI categories, but the association was stronger with genetically predicted lower BMI (hazard ratio from 1.55 to 2.08 for those with high and low PGSBMI, respectively). Within monozygotic twin pairs, the association did not differ by genetically predicted BMI, indicating genetic confounding not captured by the PGSBMI. Results were similar when obesity was measured in late-life, but suffered from low power. Obesity was associated with CVD regardless of PGSBMI category, but obesity influenced by genetic predisposition (genetically predicted high BMI) was less harmful than obesity influenced by environmental factors (obesity despite genetically predicted low BMI). However, additional genetic factors, not captured by the PGSBMI, still influence the associations. The ; ; ; the , ; the ; and the .
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DOI：
10.1177/1745691610383511
发表时间：
2010-09
期刊：
Perspectives on psychological science : a journal of the Association for Psychological Science
影响因子：
--
作者：
McGue M;Osler M;Christensen K
通讯作者：
Christensen K
影响因子：
1.9
作者：
Finkel, D;Pedersen, NL
通讯作者：
Pedersen, NL
影响因子：
7.7
作者：
McGue, Matt;Skytthe, Axel;Christensen, Kaare
通讯作者：
Christensen, Kaare
影响因子：
9.3
作者：
Karlsson, Ida K.;Lehto, Kelli;Dahl Aslan, Anna K.
通讯作者：
Dahl Aslan, Anna K.
影响因子：
6.7
作者：
Dahl, Anna K.;Hassing, Linda B.;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.