Neuroendocrine control of Drosophila larval light preference.

Neuroendocrine control of Drosophila larval light preference.
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DOI:
10.1126/science.1241210
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发表时间:
2013-09-06
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Léopold P
Léopold P
中科院分区:
其他
文献类型:
--
作者:
Yamanaka N;Romero NM;Martin FA;Rewitz KF;Sun M;O'Connor MB;Léopold P

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Animal development is coupled with innate behaviors that maximize chances of survival. Here we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors, the Bolwig’s organ and the peripheral class IV dendritic arborization neurons, to regulate light avoidance. We find that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, thereby driving animals towards a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.
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