Progressive Multiple Sclerosis Is Associated with Faster and Specific Retinal Layer Atrophy.
Progressive Multiple Sclerosis Is Associated with Faster and Specific Retinal Layer Atrophy.
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DOI：
10.1002/ana.25738
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发表时间：
2020-06
影响因子：
11.2
通讯作者：
International Multiple Sclerosis Visual System (IMSVISUAL) Consortium
中科院分区：
文献类型：
--
作者：
Sotirchos ES;Gonzalez Caldito N;Filippatou A;Fitzgerald KC;Murphy OC;Lambe J;Nguyen J;Button J;Ogbuokiri E;Crainiceanu CM;Prince JL;Calabresi PA;Saidha S;International Multiple Sclerosis Visual System (IMSVISUAL) Consortium
由于缺乏可靠的生物标志物来监测神经变性，进展性多发性硬化症（PMS）的治疗发展受到阻碍。光学相干断层扫描（OCT）衍生的视网膜测量已被提出作为有前途的生物标志物来履行这一作用。然而，目前尚不清楚经前综合征的视网膜萎缩是否持续，是否超过正常的衰老，或者是否可以与复发-缓解型MS （RRMS）区分开来。178名RRMS患者、186名PMS患者和66名对照患者接受连续OCT随访，中位随访时间为3.7年。MS中因正常衰老导致的乳头周围视网膜神经纤维层（pRNFL）和黄斑神经节细胞+内丛状层（GCIPL）变薄的估计比例分别从25岁时的42.7%和16.7%增加到65岁时的83.7%和81.1%。然而，与RRMS相比，与年龄无关，PMS与更快的pRNFL（- 0.34±0.09%/年，p<0.001）和GCIPL（- 0.27±0.07%/年，p<0.001）变薄相关。在MS和对照组中，较高的基线年龄与更快的内（INL）和外核层（ONL）变薄有关。PMS组的INL和ONL分别比对照组（INL:−0.09±0.04%/年，p=0.03; ONL:−0.12±0.06%/年，p=0.04）和RRMS组（INL:−0.10±0.04%/年，p=0.01; ONL:−0.13±0.05%/年，p=0.01）更快，RRMS组和对照组相似。与RRMS不同，疾病改善疗法（DMTs）对经前综合征的视网膜层萎缩率没有影响。经前症候群与视网膜快速萎缩有关，与年龄无关。INL和ONL测量可能是经前症候群神经退行性变的新生物标志物，似乎不受传统dmt的影响。在结合OCT结果的临床试验中，应考虑衰老对视网膜层萎缩率的影响。
Therapeutic development in progressive multiple sclerosis (PMS) has been hampered by a lack of reliable biomarkers to monitor neurodegeneration. Optical coherence tomography (OCT)-derived retinal measures have been proposed as promising biomarkers to fulfill this role. However, it is unclear if retinal atrophy persists in PMS, exceeds normal aging, or can be distinguished from relapsing-remitting MS (RRMS). 178 RRMS, 186 PMS, and 66 control participants were followed with serial OCT for a median follow-up of 3.7 years. The estimated proportion of peri-papillary retinal nerve fiber layer (pRNFL) and macular ganglion cell+inner plexiform layer (GCIPL) thinning in MS attributable to normal aging increased from 42.7% and 16.7% respectively at age 25 years, to 83.7% and 81.1% at age 65 years. However, independent of age, PMS was associated with faster pRNFL (−0.34±0.09%/year; p<0.001) and GCIPL (−0.27±0.07%/year; p<0.001) thinning, as compared to RRMS. In both MS and controls, higher baseline age was associated with faster inner (INL) and outer nuclear layer (ONL) thinning. INL and ONL thinning were independently faster in PMS, as compared to controls (INL:−0.09±0.04%/year, p=0.03; ONL:−0.12±0.06%/year, p=0.04), and RRMS (INL:−0.10±0.04%/year, p=0.01; ONL:−0.13±0.05%/year, p=0.01), while they were similar in RRMS and controls. Unlike RRMS, disease-modifying therapies (DMTs) did not impact rates of retinal layer atrophy in PMS. PMS is associated with faster retinal atrophy independent of age. INL and ONL measures may be novel biomarkers of neurodegeneration in PMS, that appear to be unaffected by conventional DMTs. The effects of aging on rates of retinal layer atrophy should be considered in clinical trials incorporating OCT outcomes.
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DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
9.9
作者：
Lublin FD;Reingold SC;Cohen JA;Cutter GR;Sørensen PS;Thompson AJ;Wolinsky JS;Balcer LJ;Banwell B;Barkhof F;Bebo B Jr;Calabresi PA;Clanet M;Comi G;Fox RJ;Freedman MS;Goodman AD;Inglese M;Kappos L;Kieseier BC;Lincoln JA;Lubetzki C;Miller AE;Montalban X;O'Connor PW;Petkau J;Pozzilli C;Rudick RA;Sormani MP;Stüve O;Waubant E;Polman CH
通讯作者：
Polman CH
影响因子：
11.2
作者：
Hawker, Kathleen;O'Connor, Paul;Smith, Craig H.
通讯作者：
Smith, Craig H.
影响因子：
2.5
作者：
Bhargava P;Lang A;Al-Louzi O;Carass A;Prince J;Calabresi PA;Saidha S
通讯作者：
Saidha S
影响因子：
3.7
作者：
Gelfand JM;Goodin DS;Boscardin WJ;Nolan R;Cuneo A;Green AJ
通讯作者：
Green AJ