Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypes.
Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypes.
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DOI：
10.1371/journal.pone.0036847
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Green AJ
中科院分区：
文献类型：
--
作者：
Gelfand JM;Goodin DS;Boscardin WJ;Nolan R;Cuneo A;Green AJ
为了确定在临床孤立综合征(CIS)患者中是否可以检测到视网膜轴突丢失，首次临床脱髓鞘发作提示多发性硬化症(MS)，并检查MS疾病亚型的视网膜轴突丢失模式。对541例MS患者进行光谱域光学相干断层扫描，其中高危CIS患者45例，复发缓解(RR)MS 403例，继发进展型(SP)MS 60例，原发进展型(PP)MS 33例，正常对照53例。用多元线性回归分析视网膜神经纤维层(RNFL)厚度和黄斑体积的差异，并通过横断面分析检查年龄和病程的相关性。在无视神经炎临床病史的患者中(称为“无视神经炎的眼”)，CIS患者的总视网膜神经纤维层和颞叶乳头状RNFL较对照组薄(校正年龄和性别后的−为5.4微米[95%CI−0.9至−9.9微米，p = 0.0 2])。临床病程小于1年的CIS患者，其总体(p = 0.0 1)和颞叶(p = 0.0 3)RNFL也较对照组薄。在无视神经炎的眼组中，原发性和继发性进展性多发性硬化症患者的总视网膜神经纤维层厚度和颞叶RNFL厚度几乎相同，但总黄斑体积在原发进展性多发性硬化症患者中略低(p<；0.05)。视网膜轴突丢失在疾病的进展性阶段--进展性MS和GT；RRMS>；CIS--中日益突出，在以前受到临床明显视神经炎影响的眼睛中比例更大的变薄。视网膜轴突丢失在MS病程早期开始，在没有临床明显视神经炎的情况下，进行性MS亚型之间的RNFL变薄几乎相同。
To determine whether retinal axonal loss is detectable in patients with a clinically isolated syndrome (CIS), a first clinical demyelinating attack suggestive of multiple sclerosis (MS), and examine patterns of retinal axonal loss across MS disease subtypes. Spectral-domain Optical Coherence Tomography was performed in 541 patients with MS, including 45 with high-risk CIS, 403 with relapsing-remitting (RR)MS, 60 with secondary-progressive (SP)MS and 33 with primary-progressive (PP)MS, and 53 unaffected controls. Differences in retinal nerve fiber layer (RNFL) thickness and macular volume were analyzed using multiple linear regression and associations with age and disease duration were examined in a cross-sectional analysis. In eyes without a clinical history of optic neuritis (designated as “eyes without optic neuritis”), the total and temporal peripapillary RNFL was thinner in CIS patients compared to controls (temporal RNFL by −5.4 µm [95% CI −0.9 to −9.9 µm, p = 0.02] adjusting for age and sex). The total (p = 0.01) and temporal (p = 0.03) RNFL was also thinner in CIS patients with clinical disease for less than 1 year compared to controls. In eyes without optic neuritis, total and temporal RNFL thickness was nearly identical between primary and secondary progressive MS, but total macular volume was slightly lower in the primary progressive group (p<0.05). Retinal axonal loss is increasingly prominent in more advanced stages of disease – progressive MS>RRMS>CIS – with proportionally greater thinning in eyes previously affected by clinically evident optic neuritis. Retinal axonal loss begins early in the course of MS. In the absence of clinically evident optic neuritis, RNFL thinning is nearly identical between progressive MS subtypes.
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影响因子：
11.2
作者：
Gourraud, Pierre-Antoine;McElroy, Joseph P.;Oksenberg, Jorge R.
通讯作者：
Oksenberg, Jorge R.
影响因子：
2.5
作者：
Azevedo, Frederico A. C.;Carvalho, Ludmila R. B.;Herculano-Houzel, Suzana
通讯作者：
Herculano-Houzel, Suzana
影响因子：
3.9
作者：
Blumenthal, E. Z.;Parikh, R. S.;Thomas, R.
通讯作者：
Thomas, R.
DOI：
10.1177/1352458510382017
发表时间：
2011-01-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Kallenbach, Klaus;Sander, Birgit;Frederiksen, Jette L.
通讯作者：
Frederiksen, Jette L.
DOI：
10.3129/i10-063
发表时间：
2010-10-01
影响因子：
4.2
作者：
Costello, Fiona;Hodge, William;Freedman, Mark S.
通讯作者：
Freedman, Mark S.