Host and Bacterial Factors Associated with Haemophilus influenzae Type b Disease in Minnesota Children Vaccinated with Type b Polysaccharide Vaccine
Host and Bacterial Factors Associated with Haemophilus influenzae Type b Disease in Minnesota Children Vaccinated with Type b Polysaccharide Vaccine
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明尼苏达州儿童接种 b 型多糖疫苗后与 b 型流感嗜血杆菌疾病相关的宿主和细菌因素
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
M. Osterholm
中科院分区：
文献类型：
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作者：
D. Granoff;K. Sheetz;J. Pandey;M. Nahm;J. H. Rambeck;J. L. Jacobs;J. Musser;R. Selander;M. Kabeer;T. Murphy;M. Osterholm
对明尼苏达州接种b型多糖疫苗后主动监测发现的86例儿童乙型流感嗜血杆菌感染情况进行宿主和细菌因素分析。儿童的年龄在2-6岁之间。33人(38970)接种了疫苗。免疫接种组和未接种组低血清免疫球蛋白M、免疫球蛋白A、免疫球蛋白和免疫球蛋白G2的发生率分别为13.0%和8.0%，差异无统计学意义(P=0.5)。GM免疫球蛋白异型表型(1，3，17；23；5，13，21)的存在，以前与其他州儿童疫苗失败的相对风险较低相关，与明尼苏达州疫苗失败的相对风险降低四倍相关(P<；.07)。来自58名儿童的嗜血杆菌分离株可通过多位点电泳和外膜蛋白亚型进行克隆鉴定。在接种疫苗和未接种疫苗的患者中，致病菌株的克隆分布没有显著差异，明尼苏达州几乎所有致病克隆都已知在美国其他地区会致病。因此，在明尼苏达州，疫苗失败很少与低丙种球蛋白血症或感染b型流感嗜血杆菌罕见克隆有关。此外，在美国其他地区，与疫苗失败相关的GM表型似乎在明尼苏达州具有保护性。
Host and bacterial factors were evaluated among 86 Minnesota children with Haemophilus influenzae type b disease detected by active surveillance after introduction of type b polysaccharide vaccine in the state. Children were 2-6 y of age. Thirty-three (38970) had been vaccinated. There was no significant difference between the frequency of low serum concentrations of IgM, IgA, IgG, or IgG2 in the vaccinated and nonvaccinated subjects (13^0 vs. 8^0, P = .5). The presence of the Gm immunoglobulin allotype phenotype (1,3,17;23;5,13,21), previously associated with a lower relative risk of vaccine failure in children from other states, was associated with a fourfold decrease in the relative risk of vaccine failure in Minnesota (P < .07). Haemophilus isolates from 58 of the children were available for clonal characterization by multilocus electrophoresis and outer membrane protein subtyping. There were no significant differences between the clone distribution of the strains causing disease in vaccinated and nonvaccinated patients, and nearly all disease-producing clones in Minnesota also are known to cause disease in other areas of the country. Thus, vaccine failure in Minnesota is infrequently associated with hypogammaglobulinemia or with infection by unusual clones of a H. influenzae type b. Also, the Gm phenotype associated with protection against vaccine failure in other areas of the USA appears to be protective in Minnesota.
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菌株依赖性 IgG 亚类反应模式。
DOI：
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发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Slack,JH
通讯作者：
Slack,JH
IgA 通过不同的分子机制阻断 IgM 和 IgG 引发的免疫裂解。
DOI：
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发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Griffiss,JM;Goroff,DK
通讯作者：
Goroff,DK
德克萨斯州达拉斯县和明尼苏达州 B 型流感嗜血杆菌疾病的前瞻性监测。
影响因子：
8
作者：
Murphy,TV;Osterholm,MT;Pierson,LM;White,KE;Breedlove,JA;Seibert,GB;Kuritsky,JN;Granoff,DM
通讯作者：
Granoff,DM
与 G2m(23) 免疫球蛋白同种异型相关的基因调节对 b 型流感嗜血杆菌多糖疫苗的 IgG 亚类反应。
DOI：
10.1093/infdis/157.6.1142
发表时间：
1988
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Granoff,DM;Suarez,BK;Pandey,JP;Shackelford,PG
通讯作者：
Shackelford,PG
流行性脑膜炎球菌病：假设免疫流行病学模型的综合。
DOI：
10.1093/clinids/4.1.159
发表时间：
1982
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Griffiss,JM
通讯作者：
Griffiss,JM