Cognitive functioning in breast cancer survivors: a controlled comparison.
Cognitive functioning in breast cancer survivors: a controlled comparison.
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DOI：
10.1002/cncr.24192
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发表时间：
2009-04-15
期刊：
影响因子：
6.2
通讯作者：
Jacobsen PB
中科院分区：
文献类型：
--
作者：
Jim HS;Donovan KA;Small BJ;Andrykowski MA;Munster PN;Jacobsen PB
确定辅助治疗完成后6个月的乳腺癌幸存者与未患癌症的女性相比，神经心理功能是否有所不同。参与者是187名被诊断为导管原位癌（DCIS）、I期或II期乳腺癌的女性，以及187名年龄和地理位置匹配的未患癌症的女性。在幸存者中，97例术后仅接受化疗或化疗加放疗，90例术后仅接受放疗。在接受化疗的幸存者及其匹配的对照组中，以及仅接受放疗的幸存者及其匹配的对照组中，观察到认知功能和认知障碍的微小但具有统计学意义的差异。在认知抱怨方面没有观察到组间差异。目前研究的数据表明，认知缺陷是微妙的，可能是由于癌症诊断和治疗的一般影响，而不是全身治疗。
To determine whether neuropsychological functioning differs in breast cancer survivors six months after completion of adjuvant treatment as compared to women without cancer. Participants were 187 women diagnosed with ductal carcinoma in situ (DCIS), Stage I, or Stage II breast cancer and 187 age- and geographic- matched women without cancer. Of survivors, 97 had been treated post-surgery with chemotherapy only or chemotherapy plus radiotherapy and 90 had been treated post-surgery with radiotherapy only. Small but statistically significant differences in cognitive functioning and cognitive impairment were observed in survivors treated with chemotherapy and their matched controls and also in survivors treated with radiotherapy only and their matched controls. No group differences were observed in cognitive complaints. Data from the current study suggest that cognitive deficits are subtle and likely due to the general effects of cancer diagnosis and treatment rather than systemic treatment.
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影响因子：
45.3
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通讯作者：
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