What is an "adverse" environment? Interactions of rearing experiences and MAOA genotype in rhesus monkeys.
What is an "adverse" environment? Interactions of rearing experiences and MAOA genotype in rhesus monkeys.
复制标题
DOI：
10.1016/j.biopsych.2008.11.004
复制
发表时间：
2009-05-01
影响因子：
10.6
通讯作者：
Capitanio, John P.
中科院分区：
文献类型：
--
作者：
Karere, Genesio M.;Kinnally, Erin L.;Sanchez, Jessica N.;Famula, Thomas R.;Lyons, Leslie A.;Capitanio, John P.
研究一直不一致，表明早期逆境和特定基因型可能是不良行为结果的联合风险因素。使用恒河猴模型，我们研究了社会背景和不同形式的早期逆境如何影响特定基因型（单胺氧化酶A启动子区的多态性）是否会影响攻击性，恐惧和焦虑行为的表现。恒河猴婴儿（n=473）在3-4个月大时暴露于短暂的社会挑战。幼仔被饲养：a）在大笼子里与母亲和多达150只其他动物一起饲养; B）在较小的社会群体中与母亲一起饲养; c）与母亲一起饲养，最多可以接触到另一对母婴; d）没有母亲，但可以在托儿所接触到同龄同伴。没有发现基因型的影响，在大的社会笼子里的母亲养育的婴儿，虽然几个基因型养育环境的相互作用是显而易见的。在较小的社会群体中饲养的动物更有可能表现出攻击性，尤其是那些具有低活性MAOA基因型的动物。此外，经历过限制性母亲养育的低活动基因型动物表现出更多的焦虑行为（抓挠，打哈欠）。在母亲饲养的动物中，与母亲的社会环境和经验相关的更广泛的背景特征可以影响基因型在挑战条件下对行为表达的贡献程度。研究结果还表明，不同形式的早期不良经历会影响不同基因型动物的反应类型。
Studies have been inconsistent in demonstrating that early adversity and specific genotype can be joint risk factors for poor behavioral outcomes. Using a rhesus monkey model, we examined how social context and different forms of early adversity influence whether a specific genotype (polymorphism in the promoter region of monoamine oxidase A) affects display of aggressive, fearful, and anxious behaviors. Rhesus monkey infants (n=473) were exposed to brief social challenge at 3–4 months of age. Infants were reared a) with mothers and up to 150 other animals in large cages; b) with mothers in smaller social groups; c) with mother and access to, at most, one other mother-infant pair; and d) without mother, but with access to a same-aged peer in a nursery. No effects of genotype were found for infants reared by mothers in large social cages, although several genotype by rearing environment interactions were evident. Animals reared in smaller social groups were more likely to display aggression, which was especially true of animals possessing the low-activity MAOA genotype. In addition, animals with low-activity genotypes that had experienced restricted mother-rearing showed more anxious behavior (scratch, yawn). Among mother-reared animals, broader contextual features, associated with the social environment and experience of the mother, can affect the extent to which genotype contributes to behavioral expression under conditions of challenge. Results also suggest that different forms of early adverse experience can affect the types of responses displayed by animals of different genotypes.
登录
查看更多内容
影响因子：
10.6
作者：
Huizinga, David;Haberstick, Brett C.;Hewitt, John K.
通讯作者：
Hewitt, John K.
影响因子：
1.7
作者：
TANAKA, I
通讯作者：
TANAKA, I
影响因子：
56.9
作者：
Caspi, A;McClay, J;Poulton, R
通讯作者：
Poulton, R
影响因子：
56.9
作者：
KALIN, NH;SHELTON, SE
通讯作者：
SHELTON, SE
早期创伤和成年期间身体攻击的风险增加：MAOA基因型的调节作用。
影响因子：
3.7
作者：
Frazzetto, Giovanni;Di Lorenzo, Giorgio;Carola, Valeria;Proietti, Luca;Sokolowska, Ewa;Siracusano, Alberto;Gross, Cornelius;Troisi, Alfonso
通讯作者：
Troisi, Alfonso