Transcriptional regulation by HMGN proteins.

Transcriptional regulation by HMGN proteins.
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DOI:
10.1016/j.bbagrm.2009.11.006
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发表时间:
2010-01
影响因子:
4.7
通讯作者:
Hansen, Ulla
Hansen, Ulla
中科院分区:
生物学2区
文献类型:
--
作者:
Zhu, Nan;Hansen, Ulla

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高迁移率族核小体蛋白(HMGN)是一类与染色质相关的非组蛋白小分子蛋白。HMGN具有独特的能力,以比裸DNA更高的亲和力结合核小体[1]。它们因其调节转录的能力而被广泛研究。虽然最初被视为染色质模板上的一般转录激活因子,但现在认识到它们是基因表达的高度特异性调节剂。我们回顾了HMGNs靶向特定基因的机制,以及它们随后如何调节转录。
High mobility group nucleosomal proteins (HMGNs) are small non-histone proteins associated with chromatin. HMGNs have the unique ability to bind to nucleosomes with higher affinity than to naked DNA [1]. They have been studied extensively for their ability to modulate transcription. Although initially viewed as general transcriptional activators on chromatin templates, it is now appreciated that they are instead highly specific modulators of gene expression. We review the mechanisms for targeting HMGNs to specific genes and for how they subsequently regulate transcription.
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