T Cell Response to SARS-CoV-2 Coinfection and Comorbidities.
T Cell Response to SARS-CoV-2 Coinfection and Comorbidities.
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DOI:
10.3390/pathogens12020321
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发表时间:
2023-02-15
期刊:
影响因子:
--
通讯作者:
Song J
中科院分区:
文献类型:
--
作者:
Wang L;Peng HY;Pham A;Villazana E;Ballard DJ;Das JK;Kumar A;Xiong X;Song J
For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses are also impacted by many other pathogens and chronic diseases. We have summarized T cell performance during SARS-CoV-2 coinfection with other viruses, bacteria, and parasites. Furthermore, we distinguished if those altered T cell statuses under coinfection would affect their clinical outcomes, such as symptom severity and hospitalization demand. T cell alteration in diabetes, asthma, and hypertension patients with SARS-CoV-2 infection was also investigated in our study. We have summarized whether changes in T cell response influence the clinical outcome during comorbidities.
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Viruses
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