T Cell Response to SARS-CoV-2 Coinfection and Comorbidities.

T Cell Response to SARS-CoV-2 Coinfection and Comorbidities.
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DOI:
10.3390/pathogens12020321
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发表时间:
2023-02-15
期刊:
Pathogens (Basel, Switzerland)
影响因子:
--
通讯作者:
Song J
Song J
中科院分区:
其他
文献类型:
--
作者:
Wang L;Peng HY;Pham A;Villazana E;Ballard DJ;Das JK;Kumar A;Xiong X;Song J

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过去三年,COVID-19已成为日益严重的全球健康问题。适应性免疫细胞,特别是T细胞,在SARS-CoV-2感染方面已被广泛研究。然而,人类健康和T细胞反应也受到许多其他病原体和慢性疾病的影响。我们总结了SARS-CoV-2与其他病毒、细菌和寄生虫共感染期间T细胞的表现。此外,我们区分了合并感染下这些改变的T细胞状态是否会影响其临床结果,如症状严重程度和住院需求。我们的研究还调查了糖尿病、哮喘和高血压患者感染SARS-CoV-2后的T细胞改变。我们总结了T细胞反应的变化是否会影响合并症的临床结果。
For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses are also impacted by many other pathogens and chronic diseases. We have summarized T cell performance during SARS-CoV-2 coinfection with other viruses, bacteria, and parasites. Furthermore, we distinguished if those altered T cell statuses under coinfection would affect their clinical outcomes, such as symptom severity and hospitalization demand. T cell alteration in diabetes, asthma, and hypertension patients with SARS-CoV-2 infection was also investigated in our study. We have summarized whether changes in T cell response influence the clinical outcome during comorbidities.
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