Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity.
Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity.
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DOI：
10.1038/s41467-021-26113-1
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发表时间：
2021-10-05
影响因子：
16.6
通讯作者：
Israely T
中科院分区：
文献类型：
--
作者：
Achdout H;Vitner EB;Politi B;Melamed S;Yahalom-Ronen Y;Tamir H;Erez N;Avraham R;Weiss S;Cherry L;Bar-Haim E;Makdasi E;Gur D;Aftalion M;Chitlaru T;Vagima Y;Paran N;Israely T
严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）是2019冠状病毒病（COVID-19）大流行的原因。SARS-CoV-2的持续传播增加了流感/SARS-CoV-2合并感染的可能性，这可能导致严重的疾病。在这项研究中，我们研究了甲型流感病毒（IAV）和SARS-CoV-2共感染K18-hACE 2小鼠的疾病结果。我们的数据表明，IAV感染的小鼠在两天后与SARS-CoV-2共感染后对发展严重疾病的易感性增强。与SARS-CoV-2单独引起的非致命性流感和较低的死亡率相反，这种合并感染导致严重的发病率和几乎完全的死亡率。合并感染与呼吸器官中流感病毒载量升高有关。值得注意的是，先前对流感的免疫，而不是对SARS-CoV-2的免疫，可以预防严重的疾病和死亡。这种保护是抗体依赖性的。这些数据通过实验支持季节性流感疫苗接种的必要性，以降低COVID-19大流行期间严重流感/COVID-19合并症的风险。在流感季节，甲型流感病毒（IAV）和SARS-CoV-2合并感染是一种可能的情况。在这里，作者在小鼠模型中表明，IAV感染增加了SARS-CoV-2感染两天后严重疾病的风险。IAV疫苗接种，特别是抗体依赖性疫苗接种，可在合并感染期间预防严重疾病。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. The continued spread of SARS-CoV-2 increases the probability of influenza/SARS-CoV-2 coinfection, which may result in severe disease. In this study, we examine the disease outcome of influenza A virus (IAV) and SARS-CoV-2 coinfection in K18-hACE2 mice. Our data indicate enhance susceptibility of IAV-infected mice to developing severe disease upon coinfection with SARS-CoV-2 two days later. In contrast to nonfatal influenza and lower mortality rates due to SARS-CoV-2 alone, this coinfection results in severe morbidity and nearly complete mortality. Coinfection is associated with elevated influenza viral loads in respiratory organs. Remarkably, prior immunity to influenza, but not to SARS-CoV-2, prevents severe disease and mortality. This protection is antibody-dependent. These data experimentally support the necessity of seasonal influenza vaccination for reducing the risk of severe influenza/COVID-19 comorbidity during the COVID-19 pandemic. Influenza A virus (IAV) and SARS-CoV-2 coinfection is a possible scenario during influenza season. Here, the authors show in a mouse model that IAV infection increases the risk of severe disease upon SARS-CoV-2 infection two days later. IAV vaccination, especially antibody-dependent, protects from severe disease during coinfection.
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DOI：
10.1016/j.ijid.2021.02.087
发表时间：
2021-04
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Singh V;Upadhyay P;Reddy J;Granger J
通讯作者：
Granger J
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
DOI：
10.1074/jbc.ac120.013788
发表时间：
2020-10-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Felgenhauer U;Schoen A;Gad HH;Hartmann R;Schaubmar AR;Failing K;Drosten C;Weber F
通讯作者：
Weber F
影响因子：
3.7
作者：
McAfee, Megan S.;Huynh, Trung P.;Blattman, Joseph N.
通讯作者：
Blattman, Joseph N.
影响因子：
6.4
作者：
Laurie, Karen L.;Horman, William;Barr, Ian G.
通讯作者：
Barr, Ian G.