Emerging Roles of BRD7 in Pathophysiology.
Emerging Roles of BRD7 in Pathophysiology.
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DOI：
10.3390/ijms21197127
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发表时间：
2020-09-27
影响因子：
5.6
通讯作者：
Lee JM
中科院分区：
文献类型：
--
作者：
Park SW;Lee JM
溴结构域是一种存在于许多染色质相关蛋白中的保守结构模块。含溴结构域蛋白7（BRD7）是含溴结构域蛋白家族的成员，并且在二十年前被发现为在鼻咽癌中下调的蛋白。从那时起，BRD7已经涉及各种细胞过程，包括染色质重塑，转录调控和细胞周期进程。BRD7活性降低是不同器官中各种疾病的病理生理学特性的基础。BRD7在许多癌症的发病机制中起着重要作用，最近，它在代谢和肥胖调节中的作用也得到了强调。在这里，我们回顾了BRD7在各种病理生理条件下的参与，重点是葡萄糖稳态，肥胖和癌症。
Bromodomain is a conserved structural module found in many chromatin-associated proteins. Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family, and was discovered two decades ago as a protein that is downregulated in nasopharyngeal carcinoma. Since then, BRD7 has been implicated in a variety of cellular processes, including chromatin remodeling, transcriptional regulation, and cell cycle progression. Decreased BRD7 activity underlies the pathophysiological properties of various diseases in different organs. BRD7 plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism and obesity have also been highlighted. Here, we review the involvement of BRD7 in a variety of pathophysiological conditions, with a focus on glucose homeostasis, obesity, and cancer.
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影响因子：
2.2
作者：
Dolenšek J;Rupnik MS;Stožer A
通讯作者：
Stožer A
影响因子：
--
作者：
Heo JI;Kim W;Choi KJ;Bae S;Jeong JH;Kim KS
通讯作者：
Kim KS
DOI：
10.1073/pnas.0908899107
发表时间：
2010-03-23
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
64.8
作者：
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影响因子：
3.5
作者：
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通讯作者：
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