Regulatory effects of protein S-acylation on insulin secretion and insulin action.
Regulatory effects of protein S-acylation on insulin secretion and insulin action.
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蛋白质S-酰化对胰岛素分泌和胰岛素作用的调节作用。
DOI：
10.1098/rsob.210017
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发表时间：
2021-03
期刊：
影响因子：
5.8
通讯作者：
Gould GW
中科院分区：
文献类型：
--
作者：
Chamberlain LH;Shipston MJ;Gould GW
翻译后修饰(PTM)，如磷酸化和泛素化，是被广泛研究的事件，在细胞功能的各个方面都具有公认的重要性。相比之下，蛋白质S酰化虽然是一种广泛存在的、在大多数生理系统中具有重要功能的PTM，但受到的关注要少得多。S酰化的干扰与包括智力障碍、癌症和糖尿病在内的各种疾病有关，这表明这种较少研究的修饰可能具有相当大的生物学意义。作为一个范例，在这篇综述中，我们重点介绍了S酰化和激素胰岛素之间的新出现的联系。具体地说，我们研究了S酰化如何调节胰岛素分泌和胰岛素反应途径的关键成分。讨论的蛋白质突出了S酰化修饰的多种蛋白质，包括通道、转运体、受体和运输蛋白，也说明了S酰化对这些蛋白质的不同影响，从膜结合和微观定位到调节蛋白质分类和蛋白质相互作用。
Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function. By contrast, protein S-acylation, although a widespread PTM with important functions in most physiological systems, has received far less attention. Perturbations in S-acylation are linked to various disorders, including intellectual disability, cancer and diabetes, suggesting that this less-studied modification is likely to be of considerable biological importance. As an exemplar, in this review, we focus on the newly emerging links between S-acylation and the hormone insulin. Specifically, we examine how S-acylation regulates key components of the insulin secretion and insulin response pathways. The proteins discussed highlight the diverse array of proteins that are modified by S-acylation, including channels, transporters, receptors and trafficking proteins and also illustrate the diverse effects that S-acylation has on these proteins, from membrane binding and micro-localization to regulation of protein sorting and protein interactions.
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DOI：
10.1113/jp272262
发表时间：
2016-10-01
期刊：
The Journal of physiology
影响因子：
--
作者：
Dolphin AC
通讯作者：
Dolphin AC
Rab10 和肌球蛋白-Va 介导脂肪细胞中胰岛素刺激的 GLUT4 储存囊泡易位
DOI：
10.1083/jcb.201111091
发表时间：
2012-08-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chen Y;Wang Y;Zhang J;Deng Y;Jiang L;Song E;Wu XS;Hammer JA;Xu T;Lippincott-Schwartz J
通讯作者：
Lippincott-Schwartz J
影响因子：
4.8
作者：
Chien, AJ;Gao, TY;Hosey, MM
通讯作者：
Hosey, MM
影响因子：
4.1
作者：
Brewer, Paul Duffield;Habtemichael, Estifanos N.;Mastick, Cynthia Corley
通讯作者：
Mastick, Cynthia Corley
影响因子：
4.8
作者：
Duncan, Peter J.;Bi, Danlei;Shipston, Michael J.
通讯作者：
Shipston, Michael J.