Biological Treatments in Atopic Dermatitis.

Biological Treatments in Atopic Dermatitis.
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DOI:
10.3390/jcm4040593
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发表时间:
2015-04-03
影响因子:
3.9
通讯作者:
Sánchez-Pérez J
Sánchez-Pérez J
中科院分区:
医学2区
文献类型:
--
作者:
Montes-Torres A;Llamas-Velasco M;Pérez-Plaza A;Solano-López G;Sánchez-Pérez J

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特应性皮炎(AD)是影响儿童和成人的最常见的慢性炎症性皮肤病之一,患病率分别为30%和10%。尽管大多数患者对局部抗炎药物的反应令人满意,但约10%的患者需要一种或多种全身治疗来实现对疾病的良好控制。随着对AD免疫发病机制的深入了解,人们开始研究新的治疗靶点,并在生物治疗领域取得了非常有前途的结果。在这篇文章中,我们将回顾不同的生物治疗,重点是新药。将详细说明其作用机制、当前状态以及临床试验和观察性研究的结果。
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases that affect both children and adults with a prevalence of 30% and 10%, respectively. Even though most of patients respond satisfactory to topical anti-inflammatory drugs, about 10% require one or more systemic treatments to achieve good control of their illness. The progressive and increasingly detailed knowledge in the immunopathogenesis of AD has allowed research on new therapeutic targets with very promising results in the field of biological therapy. In this article, we will review the different biological treatments with a focus on novel drugs. Their mechanism of action, current status and results from clinical trials and observational studies will be specified.
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