Real-time fMRI feedback impacts brain activation, results in auditory hallucinations reduction: Part 1: Superior temporal gyrus -Preliminary evidence.
Real-time fMRI feedback impacts brain activation, results in auditory hallucinations reduction: Part 1: Superior temporal gyrus -Preliminary evidence.
复制标题
实时fMRI反馈影响大脑激活，导致幻听减少：第1部分：上级颞回-初步证据。
DOI：
10.1016/j.psychres.2020.112862
复制
发表时间：
2020-02-10
影响因子：
11.3
通讯作者：
Niznikiewicz MA
中科院分区：
文献类型：
--
作者：
Okano K;Bauer CCC;Ghosh SS;Lee YJ;Melero H;de Los Angeles C;Nestor PG;Del Re EC;Northoff G;Whitfield-Gabrieli S;Niznikiewicz MA
幻听(AH)是精神分裂症(SZ)的核心症状之一，是痛苦和残疾的重要来源。三分之一的SZ患者经历了药理耐药的AH，因此需要一种替代/补充治疗策略来缓解这种虚弱的情况。本研究利用实时功能磁共振成像神经反馈(RT-fMRI NFB)这一非侵入性技术，对10例药物性难治性脑出血的SZ患者进行了颞上回(STG)脑活动的调节。设计了一个功能性任务，以便为患者提供特定的策略，帮助他们按照所需的方向调整他们的大脑活动。具体地说，他们从自己的STG那里接受神经反馈，并接受训练，在听自己的语音记录时上调它，在忽略陌生人的语音记录时下调它。这种指导性的神经反馈训练导致a)STG激活显著减少，而忽略陌生人的声音，以及b)在神经反馈训练后AH分数降低。一次21分钟的RT-fMRI NFB治疗就足以产生这些效应，这表明这种方法可能是治疗药物耐药的AH的一种有效和临床可行的替代方法。
Auditory hallucinations (AH) are one of the core symptoms of schizophrenia (SZ) and constitute a significant source of suffering and disability. One third of SZ patients experience pharmacology-resistant AH, so an alternative/complementary treatment strategy is needed to alleviate this debilitating condition. In this study, real-time functional Magnetic Resonance Imaging neurofeedback (rt-fMRI NFB), a non-invasive technique, was used to teach 10 SZ patients with pharmacology-resistant AH to modulate their brain activity in the superior temporal gyrus (STG), a key area in the neurophysiology of AH. A functional task was designed in order to provide patients with a specific strategy to help them modify their brain activity in the desired direction. Specifically, they received neurofeedback from their own STG and were trained to upregulate it while listening to their own voice recording and downregulate it while ignoring a stranger's voice recording. This guided performance neurofeedback training resulted in a) a significant reduction in STG activation while ignoring a stranger's voice, and b) reductions in AH scores after the neurofeedback session. A single, 21-minute session of rt-fMRI NFB was enough to produce these effects, suggesting that this approach may be an efficient and clinically viable alternative for the treatment of pharmacology-resistant AH.
登录
查看更多内容
影响因子：
4.7
作者：
Fovet T;Orlov N;Dyck M;Allen P;Mathiak K;Jardri R
通讯作者：
Jardri R
影响因子：
6.6
作者：
Alderson-Day B;Diederen K;Fernyhough C;Ford JM;Horga G;Margulies DS;McCarthy-Jones S;Northoff G;Shine JM;Turner J;van de Ven V;van Lutterveld R;Waters F;Jardri R
通讯作者：
Jardri R
影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
4.5
作者：
Brent, Benjamin K.;Seidman, Larry J.;Coombs, Garth, III;Keshavan, Matcheri S.;Moran, Joseph M.;Holt, Daphne J.
通讯作者：
Holt, Daphne J.
影响因子：
5.9
作者：
Haller, Sven;Birbaumer, Niels;Veit, Ralf
通讯作者：
Veit, Ralf