Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI.
Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI.
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DOI：
10.1002/nbm.1343
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发表时间：
2009-04
影响因子：
2.9
通讯作者：
Narayana, Ponnada A.
中科院分区：
文献类型：
--
作者：
Cohen, David M.;Patel, Chirag B.;Ahobila-Vajjula, Pallavi;Sundberg, Laura M.;Chacko, Tessy;Liu, Shi-Jie;Narayana, Ponnada A.
关键词：
Following the primary traumatic injury, spinal cord tissue undergoes a series of pathobiological changes, including compromised blood-spinal cord-barrier (BSCB) integrity. These vascular changes occur over both time and space. In an experimental model of spinal cord injury (SCI), longitudinal dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)studies were performed up to 56 days post-SCI to quantify spatial and temporal changes in the BSCB permeability in tissue that did not show any visible enhancement on the post-contrast MRI(non-enhancing tissue). DCE-MRI data was analyzed using a two-compartment pharmacokinetic model. These studies demonstrate gradual restoration of BSCB with post-SCI time. But, based on DCE-MRI, and confirmed by immunohistochemistry, the BSCB remained compromised even at 56 days post-SCI. In addition, open-field locomotion was evaluated using the 21 point Basso-Beattie-Bresnahan scale. A significant correlation between decreased BSCB permeability and improved locomotor recovery was observed.
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