Intra-axonal mechanisms driving axon regeneration.
Intra-axonal mechanisms driving axon regeneration.
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DOI：
10.1016/j.brainres.2020.146864
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发表时间：
2020-08-01
期刊：
影响因子：
2.9
通讯作者：
Twiss JL
中科院分区：
文献类型：
--
作者：
Smith TP;Sahoo PK;Kar AN;Twiss JL
外周和中枢神经系统的创伤性损伤经常导致轴突切断，轴突失去与其靶点的连接，导致功能丧失。损伤部位远端的轴突节段与细胞体失去连接而变性。周围被切断轴突的神经元可以自发地启动再生反应，并重新连接到它们失神经的目标组织，尽管这在人类身上很少完成。相比之下，脊髓和脑的轴突切断后很少发生自发再生。在这里，我们集中于周围神经系统自发再生的潜在机制，重点关注从轴突启动的支持再生生长的事件。我们将其与已知的中枢神经系统轴突损伤反应进行对比。考虑到这一特殊问题的神经病变焦点，我们进一步在启动再生基因表达程序的损伤反应机制和那些已知触发轴突退化的损伤反应机制之间进行了相似和区别。
Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate. Axotomized neurons in the periphery can spontaneously mount a regenerative response and reconnect to their denervated target tissues, though this is rarely complete in humans. In contrast, spontaneous regeneration rarely occurs after axotomy in the spinal cord and brain. Here, we concentrate on the mechanisms underlying this spontaneous regeneration in the peripheral nervous system, focusing on events initiated from the axon that support regenerative growth. We contrast this with what is known for axonal injury responses in the central nervous system. Considering the neuropathy focus of this special issue, we further draw parallels and distinctions between the injury-response mechanisms that initiate regenerative gene expression programs and those that are known to trigger axon degeneration.
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影响因子：
5.7
作者：
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通讯作者：
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影响因子：
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DOI：
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DOI：
10.1523/jneurosci.4065-10.2011
发表时间：
2011-01-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
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通讯作者：
Court FA