Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival.
Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival.
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DOI：
10.1038/s42003-020-01357-7
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发表时间：
2020-10-30
影响因子：
5.9
通讯作者：
Dudbridge F
中科院分区：
文献类型：
--
作者：
Timmins IR;Zaccardi F;Nelson CP;Franks PW;Yates T;Dudbridge F
步行是一种简单的锻炼方式，因其健康益处而被广泛推广。自我报告的步行速度与一系列心肺疾病和癌症结果相关，并且是死亡率的有力预测因子。在这里，我们对 450,967 名欧洲血统英国生物银行参与者的自我报告步行速度进行了全基因组关联研究。我们确定了 70 个独立的相关位点 (P < 5 × 10−8)，其中 11 个是新的。我们估计基于 SNP 的遗传力为 13.2% (s.e.= 0.21%)，调整体重指数后降至 8.9% (s.e.= 0.17%)。观察到与心脏代谢、呼吸和精神特征、教育程度和全因死亡率之间存在显着的遗传相关性。孟德尔随机化分析表明，增加步行速度与降低心脏代谢风险之间存在潜在因果关系。鉴于其遗传力低且测量简单，这些研究结果表明，自我报告的步行速度是旨在实现总体健康益处的干预措施的务实目标。伊恩·蒂明斯等人。在英国生物银行中确定了 70 个与自我报告步行速度相关的基因座。利用孟德尔随机化，他们发现了步行速度加快与心脏代谢风险降低之间存在因果关系的证据，再加上估计的遗传力较低，表明自我报告的步行速度可能成为医疗保健干预的目标。
Walking is a simple form of exercise, widely promoted for its health benefits. Self-reported walking pace has been associated with a range of cardiorespiratory and cancer outcomes, and is a strong predictor of mortality. Here we perform a genome-wide association study of self-reported walking pace in 450,967 European ancestry UK Biobank participants. We identify 70 independent associated loci (P < 5 × 10−8), 11 of which are novel. We estimate the SNP-based heritability as 13.2% (s.e. = 0.21%), reducing to 8.9% (s.e. = 0.17%) with adjustment for body mass index. Significant genetic correlations are observed with cardiometabolic, respiratory and psychiatric traits, educational attainment and all-cause mortality. Mendelian randomization analyses suggest a potential causal link of increasing walking pace with a lower cardiometabolic risk profile. Given its low heritability and simple measurement, these findings suggest that self-reported walking pace is a pragmatic target for interventions aiming for general benefits on health. Iain Timmins et al. identify 70 loci associated with self-reported walking pace in the UK Biobank. Using Mendelian randomization, they find evidence for a causal link between increased walking pace and lower cardiometabolic risk profile, which combined with a low estimated heritability, suggests self-reported walking pace could be a target for healthcare intervention.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
遗传对人体组织基因表达的影响。
影响因子：
64.8
作者：
GTEx Consortium;Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group;Statistical Methods groups—Analysis Working Group;Enhancing GTEx (eGTEx) groups;NIH Common Fund;NIH/NCI;NIH/NHGRI;NIH/NIMH;NIH/NIDA;Biospecimen Collection Source Site—NDRI;Biospecimen Collection Source Site—RPCI;Biospecimen Core Resource—VARI;Brain Bank Repository—University of Miami Brain Endowment Bank;Leidos Biomedical—Project Management;ELSI Study;Genome Browser Data Integration &Visualization—EBI;Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz;Lead analysts:;Laboratory, Data Analysis &Coordinating Center (LDACC):;NIH program management:;Biospecimen collection:;Pathology:;eQTL manuscript working group:;Battle A;Brown CD;Engelhardt BE;Montgomery SB
通讯作者：
Montgomery SB
运转良好的老年人的步行速度缓慢和心血管死亡：前瞻性队列研究。
DOI：
10.1136/bmj.b4460
发表时间：
2009-11-10
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Dumurgier J;Elbaz A;Ducimetière P;Tavernier B;Alpérovitch A;Tzourio C
通讯作者：
Tzourio C
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.