Multiscale assembly for tissue engineering and regenerative medicine.

Multiscale assembly for tissue engineering and regenerative medicine.
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DOI:
10.1016/j.tibtech.2015.02.003
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发表时间:
2015-05
影响因子:
17.3
通讯作者:
Demirci, Utkan
Demirci, Utkan
中科院分区:
工程技术1区
文献类型:
--
作者:
Guven, Sinan;Chen, Pu;Inci, Fatih;Tasoglu, Saves;Erkmen, Burcu;Demirci, Utkan

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我们对细胞生物学及其与材料科学的整合的理解导致了可用于临床和制药应用的仿组织移植物生物工程的技术创新。天然样多尺度构建块的生物工程提供了对细胞微环境的精细控制,从而使功能组织成为可能。在这篇综述中,我们专注于组装积木从生物分子水平到毫米尺度。我们还概述了组装分子、细胞、球体和微凝胶以及实现自下而上的组织工程的技术。此外,我们讨论了驱动机制的自我和引导组装,以创建微观到宏观尺度的组织结构。
Our understanding of cell biology and its integration with materials science has led to technological innovations in the bioengineering of tissue-mimicking grafts that can be utilized in clinical and pharmaceutical applications. Bio-engineering of native-like multiscale building blocks provides refined control over the cellular microenvironment, thus enabling functional tissues. In this review, we focus on assembling building blocks from the biomolecular level to the millimeter scale. We also provide an overview of techniques for assembling molecules, cells, spheroids, and microgels and achieving bottom-up tissue engineering. Additionally, we discuss driving mechanisms for self- and guided assembly to create micro-to-macro scale tissue structures.
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