Diet-induced obesity causes cerebral vessel remodeling and increases the damage caused by ischemic stroke.
Diet-induced obesity causes cerebral vessel remodeling and increases the damage caused by ischemic stroke.
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DOI：
10.1016/j.mvr.2009.04.004
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发表时间：
2009-06
影响因子：
3.1
通讯作者：
Dorrance AM
中科院分区：
文献类型：
--
作者：
Deutsch C;Portik-Dobos V;Smith AD;Ergul A;Dorrance AM
喂食高脂肪(HF)食物的大鼠会出现高血压、空腹血糖升高和血浆胰岛素升高。我们的目标是评估从童年开始的肥胖对成人心血管系统的影响。我们假设喂食HF饮食的大鼠会有更大的缺血性脑梗塞和大脑中动脉(MCA)重构。给3周龄雄性SD大鼠喂食HF(肥胖)或对照饲料10周。用大脑中动脉结扎(MCAO)诱导脑缺血。未行大脑中动脉闭塞的大鼠，用压力肌图仪检测大脑中动脉结构，测定脑血管基质金属蛋白酶(MMPs)活性、表达和胶原含量。肥胖大鼠脑梗塞面积大于对照组(46.0±2.1vs28.0±7.5%)，肥胖大鼠高于对照组(P<0.05)。肥胖组大鼠大脑中动脉管腔较小(2 32±7.2vs2 5 4±7.8μ)，管壁较厚(19.6±0.8vs17.8±0.9μvs0.0 5)，顺应性较差。肥胖大鼠血管中MMP2活性和I型胶原表达增加，MMP13表达降低。这些结果表明，肥胖，从童年开始，导致向内的血管重塑，并伴随着由于胶原沉积增加而导致的血管僵硬增加。MCA结构的这些变化可能是MCAO后缺血损伤增加的原因之一。
Hypertension, elevated fasting blood glucose and plasma insulin develop in rats fed a high fat (HF) diet. Our goal was to assess the effects of obesity, beginning in childhood, on the adult cardiovascular system. We hypothesized that rats fed a HF diet would have larger ischemic cerebral infarcts and middle cerebral artery (MCA) remodeling. Three-week-old male Sprague Dawley rats were fed a HF (Obese) or control diet for 10 weeks. Cerebral ischemia was induced by MCA occlusion (MCAO). MCA structure was assessed by pressure myography and cerebral vessel matrix metalloproteinase (MMP) activity and expression and collagen levels were measured in vessels from rats that did not undergo MCAO. The cerebral infarct was greater in the obese rats than the control (46.0±2.1 vs 28.0±7.5 percent of the hemisphere infarcted, obese vs control p<0.05). The MCAs from obese rats had smaller lumens (232±7.2 vs 254±7.8μm obese vs control p<0.05) and thicker walls (19.6±0.8 vs 17.8± 0.9μm obese vs control p<0.05) and were less compliant than MCAs from control rats. MMP-2 activity and collagen I expression were increased in vessels from obese rats and MMP-13 expression was reduced. These results suggest obesity, beginning in childhood, causes inward vessel remodeling with a concomitant increase in vessel stiffness due to increased collagen deposition. These changes in MCA structure may be responsible for the increase in the ischemic damage after MCAO.
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影响因子：
120.7
作者：
Mokdad, AH;Ford, ES;Marks, JS
通讯作者：
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8.3
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