Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease.
Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease.
复制标题
转录调节中的组蛋白单泛素化及其对生命的标记：在组织发育和疾病中的新兴作用。
作者：
表观遗传调控在发育和稳态过程中驱动精确的转录程序中起着至关重要的作用。在表观遗传机制中，组蛋白单泛素化已成为一种重要的转录后修饰。两个主要的组蛋白单泛素化事件是组蛋白H2 A在赖氨酸119处的单泛素化（H2 AK 119 ub），由Polycomb抑制复合物1（PRC 1）放置，和组蛋白H2 B赖氨酸120单泛素化（H2 BK 120 ub），由异聚体RNF 20/RNF 40复合物放置。这两个事件都在塑造染色质表观遗传景观和细胞身份方面发挥着重要作用。在这篇综述中，我们总结了目前的理解背后的组蛋白单泛素化的分子概念，集中在他们最近确定的组织发育和病理作用。
Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification. Two major histone mono-ubiquitination events are the mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), placed by Polycomb repressive complex 1 (PRC1), and histone H2B lysine 120 mono-ubiquitination (H2BK120ub), placed by the heteromeric RNF20/RNF40 complex. Both of these events play fundamental roles in shaping the chromatin epigenetic landscape and cellular identity. In this review we summarize the current understandings of molecular concepts behind histone mono-ubiquitination, focusing on their recently identified roles in tissue development and pathologies.
登录
查看更多内容
影响因子：
23.9
作者：
Brookes, Emily;de Santiago, Ines;Hebenstreit, Daniel;Morris, Kelly J.;Carroll, Tom;Xie, Sheila Q.;Stock, Julie K.;Heidemann, Martin;Eick, Dirk;Nozaki, Naohito;Kimura, Hiroshi;Ragoussis, Jiannis;Teichmann, Sarah A.;Pombo, Ana
通讯作者：
Pombo, Ana
影响因子：
16
作者：
Blackledge NP;Zhou JC;Tolstorukov MY;Farcas AM;Park PJ;Klose RJ
通讯作者：
Klose RJ
影响因子：
16.6
作者：
Bakhoum MF;Francis JH;Agustinus A;Earlie EM;Di Bona M;Abramson DH;Duran M;Masilionis I;Molina E;Shoushtari AN;Goldbaum MH;Mischel PS;Bakhoum SF;Laughney AM
通讯作者：
Laughney AM
影响因子：
4.7
作者：
Cao J;Yan Q
通讯作者：
Yan Q
DOI：
10.1038/s41580-021-00398-y
发表时间：
2021-12
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Blackledge NP;Klose RJ
通讯作者：
Klose RJ