Molecular imaging in atherosclerosis.
Molecular imaging in atherosclerosis.
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DOI：
10.1007/s00259-010-1406-4
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发表时间：
2010-12
影响因子：
9.1
通讯作者：
Signore, Alberto
中科院分区：
文献类型：
--
作者：
Glaudemans, Andor W. J. M.;Slart, Riemer H. J. A.;Bozzao, Alessandro;Bonanno, Elena;Arca, Marcello;Dierckx, Rudi A. J. O.;Signore, Alberto
动脉粥样硬化是心血管疾病的主要病因，在西方世界的发病率和死亡率中仍居于领先地位。许多危险因素和病理生物学过程共同作用于动脉粥样硬化的发展。这导致了不同的重塑阶段(阳性和阴性)，这都与斑块生理和临床表现有关。不同的动脉粥样硬化重塑阶段被解释与他们的临床相关性。基础科学的最新进展表明，动脉粥样硬化不仅是一种脂肪堆积性疾病，而且炎症在疾病的所有阶段都起着基础性的作用。将对导致动脉粥样硬化的分子事件进行广泛的回顾和描述。在这篇综述中，将进一步讨论不同的方式及其在动脉粥样硬化不同阶段中的作用。对非核有创成像技术(血管内超声、血管内磁共振、冠状动脉内血管内窥镜和血管内光学相干断层扫描)和非核无创成像技术(超声多普勒、电子束CT、冠状动脉CT血管成像、MRI和冠状动脉MR血管成像)进行了综述。然后重点介绍了用于检测动脉粥样硬化斑块的核成像技术，分为三组：动脉粥样硬化病变成分、炎症和血栓形成。这一新兴的核成像技术领域可以提供动脉粥样硬化斑块生物活性的测量，从而提高对临床事件的预测。正如我们将在未来的视角中看到的那样，目前还没有一种特殊的示踪剂可以称为诊断患者未来中风或脑梗塞的诊断工具。然而，我们预计这种示踪剂将在未来几年内开发出来，理论上，它甚至可以用于靶向治疗(以贝塔发射体的形式)，以对抗心血管疾病。
Atherosclerosis is the major cause of cardiovascular disease, which still has the leading position in morbidity and mortality in the Western world. Many risk factors and pathobiological processes are acting together in the development of atherosclerosis. This leads to different remodelling stages (positive and negative) which are both associated with plaque physiology and clinical presentation. The different remodelling stages of atherosclerosis are explained with their clinical relevance. Recent advances in basic science have established that atherosclerosis is not only a lipid storage disease, but that also inflammation has a fundamental role in all stages of the disease. The molecular events leading to atherosclerosis will be extensively reviewed and described. Further on in this review different modalities and their role in the different stages of atherosclerosis will be discussed. Non-nuclear invasive imaging techniques (intravascular ultrasound, intravascular MRI, intracoronary angioscopy and intravascular optical coherence tomography) and non-nuclear non-invasive imaging techniques (ultrasound with Doppler flow, electron-bean computed tomography, coronary computed tomography angiography, MRI and coronary artery MR angiography) will be reviewed. After that we focus on nuclear imaging techniques for detecting atherosclerotic plaques, divided into three groups: atherosclerotic lesion components, inflammation and thrombosis. This emerging area of nuclear imaging techniques can provide measures of biological activity of atherosclerotic plaques, thereby improving the prediction of clinical events. As we will see in the future perspectives, at present, there is no special tracer that can be called the diagnostic tool to diagnose prospective stroke or infarction in patients. Nevertheless, we expect such a tracer to be developed in the next few years and maybe, theoretically, it could even be used for targeted therapy (in the form of a beta-emitter) to combat cardiovascular disease.
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影响因子：
24
作者：
Corti, R;Fuster, V;Badimon, JJ
通讯作者：
Badimon, JJ
影响因子：
5.5
作者：
Barrera, P;van der Laken, CJ;Corstens, FHM
通讯作者：
Corstens, FHM
影响因子：
5
作者：
Chambless, LE;Heiss, G;Clegg, LX
通讯作者：
Clegg, LX
DOI：
10.1007/s002590100572
发表时间：
2001-09-01
期刊：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
影响因子：
--
作者：
Blankenberg, FG;Tait, JF;Strauss, HW
通讯作者：
Strauss, HW
DOI：
10.1016/0735-1097(88)90356-7
发表时间：
1988-07-01
影响因子：
24
作者：
AMBROSE, JA;TANNENBAUM, MA;FUSTER, V
通讯作者：
FUSTER, V