Inflammatory bowel disease.
Inflammatory bowel disease.
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DOI：
10.1016/j.imlet.2014.04.004
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发表时间：
2014-10
影响因子：
4.4
通讯作者：
Cominelli, Fabio
中科院分区：
文献类型：
--
作者：
Corridoni, Daniele;Arseneau, Kristen O.;Cominelli, Fabio
炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC），是胃肠道的慢性、复发性炎症性疾病。CD和UC具有不同的病理和临床特征，尽管在过去几十年中进行了大量的研究，但其发病机制仍然知之甚少。迄今为止，公认的教条是IBD是由遗传易感宿主对环境因素的粘膜免疫应答失调引起的。IBD的发病机制涉及多种因素，包括遗传易感性、环境和微生物因素、肠上皮细胞以及先天性和适应性免疫系统的成分。鉴于IBD的复杂性，在过去几年中已经开发了几种不同的IBD动物模型。动物模型是研究IBD发病机制中各种因素参与的非常重要的工具，重要的是，可以测试新的治疗方案。本文综述了一些已被发现与IBD密切相关的关键组件，并描述了一些最重要的IBD模型的独特特征。
Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic, relapsing inflammatory condition of the gastrointestinal tract. CD and UC have distinct pathologic and clinical characteristics and despite the extensive amount of research conducted over the past decades, their pathogenesis remains still poorly understood. So far, the accepted dogma is that IBD results from dysregulated mucosal immune response to environmental factors in genetical susceptible hosts. Various components are implicated in the pathogenesis of IBD, including genetic susceptibility, environmental and microbial factors, intestinal epithelial cells and components of innate and adaptive immune system. Given the complexity of IBD, several different animal models of IBD have been developed during the last years. Animal models are very important tools to study the involvement of various factors in the pathogenesis of IBD and, importantly, to test new therapeutic options. This review examines some of the key components that have been found to be closely associated to IBD and describe the distinct features of some of the most important IBD models.
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