Propylene carbonate quantification by its derivative 3,5-diacetyl-1,4-dihydro-2,6-lutidine.
Propylene carbonate quantification by its derivative 3,5-diacetyl-1,4-dihydro-2,6-lutidine.
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通过其衍生物 3,5-二乙酰基-1,4-二氢-2,6-二甲基吡啶进行碳酸丙烯酯定量
DOI：
10.1016/j.talanta.2016.01.022
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发表时间：
2016
期刊：
影响因子：
6.1
通讯作者：
Lamprecht
中科院分区：
文献类型：
--
作者：
Grizić;Heimer P;Vranić;Lamprecht
碳酸丙烯酯（PC）是目前用于各种药物制剂的无毒溶剂。因此，一个简单的，具有成本效益的和最准确的分析方法，用于量化这种光学惰性溶剂的主要利益。基于连续的三步反应，从PC获得3，5-二乙酰基-1，4-二氢-2，6-二甲基吡啶，并用于通过UV和荧光检测进行定量。将数据与作为参考方法的LC-ESI-MS的结果进行比较。在使用Mandel检验对校准曲线进行线性评估后，线性拟合用于LC-ESI-MS和荧光分光光度法，而多项式三阶曲线拟合用于分光光度法。所有三种分析方法（分光光度法、荧光分光光度法和LC-ESI-MS）均证实了高日内和日间精密度以及高准确度。使用相关系数和Bland-Altman图对所有三种方法的比较进行评估，两者均显示出令人满意的结果，具有高度一致性。新方法证实了其适用于PC定量在两个配方，即PC富集霜和聚酯微植入物。这种新的PC定量方法是高度复杂的色谱方法的可靠替代品。
Propylene carbonate (PC) is a non-toxic solvent currently used in various pharmaceutical formulations. Consequently, a simple, cost-effective and most accurate analytical method for the quantification of this optical inert solvent is of major interest. Based on a consecutive three-step reaction 3,5-diacetyl-1,4-dihydro-2,6-lutidine was obtained from PC and used for quantification by either UV and fluorescent detection. Data were compared with results from LC-ESI-MS as a reference method. After using Mandel's test for linearity assessment of the calibration curves, linear fitting was used for LC-ESI-MS and spectrofluorimetry, while a polynomial 3rd order curve fitting was used for spectrophotometry. High intra- and inter-day precision as well as high accuracy were confirmed for all three analytical methods (spectrophotometry, spectrofluorimetry and LC-ESI-MS). The comparison of all three methods was assessed using correlation coefficients and Bland–Altman plots, both showing satisfying results with a high degree of agreement. The new method confirmed its applicability for PC quantification in two formulations, namely a PC-enriched cream and polyester microimplants. This new quantification method for PC is a reliable alternative to highly sophisticated chromatographic methods.
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10.1016/j.jchromb.2012.11.023
发表时间：
2013-05-15
影响因子：
3
作者：
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DOI：
10.1039/jr9590001576
发表时间：
1959
期刊：
Journal of The Chemical Society (resumed)
影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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