Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.
Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.
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DOI：
10.1146/annurev-immunol-041015-055515
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发表时间：
2016-05-20
影响因子：
29.7
通讯作者：
Hangartner L
中科院分区：
文献类型：
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作者：
Burton DR;Hangartner L
HIV采用多种手段逃避体液免疫反应，特别是广谱中和抗体(BNAbs)的诱导和识别。这种抗体可以通过靶向表面HIV包膜三聚体尖峰上相对保守的区域来对抗广泛的病毒。病毒粒子上的尖峰排列和尖峰上相对较难获得bNab表位，包括可变区和高密度的糖链，阻碍了bNAbs的激发和识别。然而，在一小部分HIV感染者中，确实产生了有效的bNab反应，通过鉴定具有有效bNab血清的有利供体和开发改进的人类抗体生成方法，促进了相应单抗的分离。对重组Env三聚体的分子研究，单独和与bNAbs的相互作用，提供了新的见解，推动了旨在诱导bNAbs的有前途的免疫原的开发和测试。
HIV employs multiple means to evade the humoral immune response, particularly the elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies can act antivirally against a wide spectrum of viruses by targeting relatively conserved regions on the surface HIV envelope trimer spike. Elicitation of and recognition by bnAbs are hindered by the arrangement of spikes on virions and the relatively difficult access to bnAb epitopes on spikes, including the proximity of variable regions and a high density of glycans. Yet, in a small proportion of HIV-infected individuals, potent bnAb responses do develop, and isolation of the corresponding monoclonal antibodies has been facilitated by identification of favorable donors with potent bnAb sera and by development of improved methods for human antibody generation. Molecular studies of recombinant Env trimers, alone and in interaction with bnAbs, are providing new insights that are fueling the development and testing of promising immunogens aimed at the elicitation of bnAbs.
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DOI：
10.1073/pnas.73.10.3671
发表时间：
1976-01-01
影响因子：
11.1
作者：
DINTZIS, HM;DINTZIS, RZ;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
影响因子：
64.8
作者：
Caskey M;Klein F;Lorenzi JC;Seaman MS;West AP Jr;Buckley N;Kremer G;Nogueira L;Braunschweig M;Scheid JF;Horwitz JA;Shimeliovich I;Ben-Avraham S;Witmer-Pack M;Platten M;Lehmann C;Burke LA;Hawthorne T;Gorelick RJ;Walker BD;Keler T;Gulick RM;Fätkenheuer G;Schlesinger SJ;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
56.9
作者：
BURTON, DR;PYATI, J;BARBAS, CF
通讯作者：
BARBAS, CF
影响因子：
3.7
作者：
Briney BS;Willis JR;Crowe JE Jr
通讯作者：
Crowe JE Jr
影响因子：
64.8
作者：
通讯作者：
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