Age differences in the prevalence and co-morbidity of DSM-IV major depressive episodes: results from the WHO World Mental Health Survey Initiative.
Age differences in the prevalence and co-morbidity of DSM-IV major depressive episodes: results from the WHO World Mental Health Survey Initiative.
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DOI：
10.1002/da.20634
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发表时间：
2010-04
影响因子：
7.4
通讯作者：
Stein, Dan J.
中科院分区：
文献类型：
--
作者：
Kessler, Ronald C.;Birnbaum, Howard G.;Shahly, Victoria;Bromet, Evelyn;Hwang, Irving;McLaughlin, Katie A.;Sampson, Nancy;Andrade, Laura Helena;de Girolamo, Giovanni;Demyttenaere, Koen;Haro, Josep Maria;Karam, Aimee N.;Kostyuchenko, Stanislav;Kovess, Viviane;Lara, Carmen;Levinson, Daphna;Matschinger, Herbert;Nakane, Yoshibumi;Browne, Mark Oakley;Ormel, Johan;Posada-Villa, Jose;Sagar, Rajesh;Stein, Dan J.
尽管抑郁症在晚年似乎有所减少，但这可能是由于将抑郁症状错误地归因于晚年增加的身体疾病。我们通过研究 WHO 世界心理健康 (WMH) 调查中 DSM-IV 重度抑郁发作 (MDE) 与慢性身体状况合并症的年龄差异来调查这个问题，该调查是在 10 个发达国家 (n = 51,771) 和 8 个发展中国家 (n = 37,265) 进行的一系列社区流行病学调查。 MDE 和其他精神障碍通过综合国际诊断访谈 (CIDI) 进行评估。没有使用有机排除规则来避免不适当地排除有身体合并症的病例。使用标准慢性病检查表评估身体状况。在发达国家（但在发展中国家），65 岁以上受访者中 12 个月的 DSM-IV/CIDI MDE 明显低于年轻受访者。共病精神障碍的患病率通常随着年龄的增长而下降或保持稳定，而 MDE 与精神障碍的共病通常随着年龄的增长而增加。相比之下，身体状况的患病率通常随着年龄的增长而增加，而 MDE 与身体状况的合并症通常随着年龄的增长而减少。发达国家和发展中国家老年人的抑郁症治疗率最低。随着年龄的增长，MDE 与身体状况之间的关联性逐渐减弱，这与以下观点相悖：老年人中 MDE 患病率较低的原因是与身体疾病的混淆程度增加。未来的研究需要调查可能导致身体疾病对老年人抑郁症影响降低的过程。
Although depression appears to decrease in late life, this could be due to misattribution of depressive symptoms to physical disorders that increase in late life. We investigated this issue by studying age differences in comorbidity of DSM-IV major depressive episodes (MDE) with chronic physical conditions in the WHO World Mental Health (WMH) surveys, a series of community epidemiological surveys carried out in 10 developed countries (n = 51,771) and 8 developing countries (n = 37,265). MDE and other mental disorders were assessed with the Composite International Diagnostic Interview (CIDI). Organic exclusion rules were not used to avoid inappropriate exclusion of cases with physical comorbidity. Physical conditions were assessed with a standard chronic conditions checklist. Twelve-month DSM-IV/CIDI MDE was significantly less prevalent among respondents ages 65+ than younger respondents in developed but not developing countries. Prevalence of comorbid mental disorders generally either decreased or remained stable with age, while comorbidity of MDE with mental disorders generally increased with age. Prevalence of physical conditions, in comparison, generally increased with age, while comorbidity of MDE with physical conditions generally decreased with age. Depression treatment was lowest among the elderly in developed and developing countries. The weakening associations between MDE and physical conditions with increasing age argue against the suggestion that the low estimated prevalence of MDE among the elderly is due to increased confounding with physical disorders. Future study is needed to investigate processes that might lead to a decreasing impact of physical illness on depression among the elderly.
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影响因子：
3.7
作者：
Diehl, M;Coyle, N;LabouvieVief, G
通讯作者：
LabouvieVief, G
影响因子：
5.7
作者：
BLAZER, D;HUGHES, DC;GEORGE, LK
通讯作者：
GEORGE, LK
DOI：
10.1093/pubmed/23.3.179
发表时间：
2001-09-01
期刊：
JOURNAL OF PUBLIC HEALTH MEDICINE
影响因子：
--
作者：
Knight, M;Stewart-Brown, S;Fletcher, L
通讯作者：
Fletcher, L
影响因子：
10.6
作者：
Bremmer, Marijke A.;Deeg, Dorly J. H.;Hoogendijk, Witte J. G.
通讯作者：
Hoogendijk, Witte J. G.
影响因子：
6.6
作者：
Bremmer, M. A.;Beekman, A. T. F.;Hoogendijk, W. J. G.
通讯作者：
Hoogendijk, W. J. G.