The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications.
The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications.
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肿瘤源性外泌体在非小细胞肺癌中的作用及其临床意义
DOI：
10.1186/s13046-018-0901-5
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发表时间：
2018-09-14
期刊：
影响因子：
--
通讯作者：
Fan S
中科院分区：
文献类型：
--
作者：
Zheng H;Zhan Y;Liu S;Lu J;Luo J;Feng J;Fan S
非小细胞肺癌（NSCLC）约占肺癌病例的85%，由于诊断时已属晚期、快速转移和复发，是全球男性和女性癌症死亡的主要原因之一。目前，针对NSCLC驱动基因的精准分子靶向治疗已取得长足进展，显着提高了NSCLC患者的总体生存率，但很容易导致获得性耐药。需要开发实时监测药物疗效和耐药性的新方法，例如用于更有效早期检测和预测预后的新分子标记。外泌体是纳米大小的细胞外囊泡，含有蛋白质、核酸和脂质，由多种细胞分泌，通过控制多种途径在肺癌的发生发展中发挥重要作用。肿瘤来源的外泌体对于指导NSCLC的靶向治疗具有重要意义，外泌体本身可以作为治疗靶点。在这篇综述中，我们描述了肿瘤源性外泌体的潜在作用及其在 NSCLC 中的临床意义。
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases, and it is one of the leading causes of cancer death in both men and women worldwide due to diagnosis in the advanced stage, rapid metastasis, and recurrence. At present, precision molecular targeted therapeutics directed toward NSCLC driven genes has made great progress and significantly improved the overall survival of patients with NSCLC, but can easily lead to acquired drug resistance. New methods are needed to develop real-time monitoring of drug efficacy and drug resistance, such as new molecular markers for more effective early detection and prediction of prognosis. Exosomes are nano-sized extracellular vesicles, containing proteins, nucleic acids and lipids, which are secreted by various cells, and they play an important role in the development of lung cancer by controlling a wide range of pathways. Tumor-derived exosomes are of great significance for guiding the targeted therapy of NSCLC and exosomes themselves can be a target for treatment. In this review, we describe the potential roles of tumor-derived exosomes and their clinical significance in NSCLC.
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影响因子：
46.9
作者：
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通讯作者：
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