Optofluidic Flow-Through Biosensor Sensitivity - Model and Experiment.

Optofluidic Flow-Through Biosensor Sensitivity - Model and Experiment.
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光流体流通生物传感器灵敏度-模型和实验。

DOI:
10.1109/jlt.2021.3061872
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发表时间:
2021-05-15
期刊:
Journal of lightwave technology : a joint IEEE/OSA publication
影响因子:
--
通讯作者:
Hawkins AR
Hawkins AR
中科院分区:
其他
文献类型:
--
作者:
Wright JG Jr;Amin MN;Meena GG;Schmidt H;Hawkins AR

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我们提出了一种基于光流体波导的荧光光学生物传感器的检测信号预测模型和仿真。典型的应用包括在标记相关DNA或RNA序列后确定生物样品中病原体浓度的流动实验。概述了生物传感器的几何形状和制造过程。本文还概述了该预测模型的基础。然后将该模型与三种不同生物传感器设计的实验结果进行比较。该模型显示出与物理测试相似的信号统计量,说明了作为预制设计工具和检测灵敏度预测器的实用性。
We present a model and simulation for predicting the detected signal of a fluorescence-based optical biosensor built from optofluidic waveguides. Typical applications include flow experiments to determine pathogen concentrations in a biological sample after tagging relevant DNA or RNA sequences. An overview of the biosensor geometry and fabrication processes is presented. The basis for the predictive model is also outlined. The model is then compared to experimental results for three different biosensor designs. The model is shown to have similar signal statistics as physical tests, illustrating utility as a pre-fabrication design tool and as a predictor of detection sensitivity.
DOI: 10.1364/oe.402311
发表时间: 2020-10-26
期刊: OPTICS EXPRESS
影响因子: 3.8
作者:
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