Primary anaplastic large cell lymphoma of the breast arising in reconstruction mammoplasty capsule of saline filled breast implant after radical mastectomy for breast cancer: an unusual case presentation.
Primary anaplastic large cell lymphoma of the breast arising in reconstruction mammoplasty capsule of saline filled breast implant after radical mastectomy for breast cancer: an unusual case presentation.
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DOI：
10.1186/1746-1596-4-11
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发表时间：
2009-04-02
影响因子：
2.6
通讯作者：
Sur M
中科院分区：
文献类型：
--
作者：
Bishara MR;Ross C;Sur M
乳腺原发性非霍奇金淋巴瘤（NHL）占乳腺恶性病变的0.04-0.5%，占结外NHL的1.7-2.2%。大多数原发病例是B细胞表型，只有极少数病例是T细胞表型。间变性大细胞淋巴瘤（ALCL）是一种罕见的T细胞淋巴瘤，通常见于儿童和年轻人，乳腺是最不常见的部位之一。文献中共描述了11例乳腺原发性ALCL病例。其中8例发生在乳房植入体附近，4例与硅胶乳房植入体相关，3例与生理盐水填充乳房植入体相关，8例植入体相关病例中有3例既往有乳腺癌手术史。仅一例患者接受了术后辅助化疗。乳腺癌化疗后继发血液恶性肿瘤已有文献报道。然而，与急性髓性白血病（AML）相比，淋巴瘤与化疗之间的关系从未得到明确证明。在这份报告中，我们介绍了一个乳房原发性ALCL的病例，该病例发生在12年前因浸润性导管癌进行根治性乳房切除术后接受术后化疗的盐水填充乳房植入体的乳房成形术胶囊中。在生理盐水填充乳房植入体部位发生的原发性ALK阴性ALCL非常罕见。目前尚不清楚化疗和乳房植入术是否会显著增加继发性血液恶性肿瘤的风险。然而，重要的是要意识到这些并发症，并需要对因植入物相关并发症而切除的组织进行仔细的病理学检查，以便做出正确的诊断，以便进一步进行患者管理和治疗。重要的是要意识到该部位的这种实体，因为它很容易在组织学基础上被误诊，并通过适当的免疫染色排除肉瘤样癌、恶性黑色素瘤和多形性肉瘤，以达到ALCL的正确诊断。
Primary non-Hodgkin lymphoma (NHL) of the breast represents 0.04–0.5% of malignant lesions of the breast and accounts for 1.7–2.2% of extra-nodal NHL. Most primary cases are of B-cell phenotype and only rare cases are of T-cell phenotype. Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma typically seen in children and young adults with the breast being one of the least common locations. There are a total of eleven cases of primary ALCL of the breast described in the literature. Eight of these cases occurred in proximity to breast implants, four in relation to silicone breast implant and three in relation to saline filled breast implant with three out of the eight implant related cases having previous history of breast cancer treated surgically. Adjuvant postoperative chemotherapy is given in only one case. Secondary hematological malignancies after breast cancer chemotherapy have been reported in literature. However in contrast to acute myeloid leukemia (AML), the association between lymphoma and administration of chemotherapy has never been clearly demonstrated. In this report we present a case of primary ALCL of the breast arising in reconstruction mamoplasty capsule of saline filled breast implant after radical mastectomy for infiltrating ductal carcinoma followed by postoperative chemotherapy twelve years ago. Primary ALK negative ALCL arising at the site of saline filled breast implant is rare. It is still unclear whether chemotherapy and breast implantation increases risk of secondary hematological malignancies significantly. However, it is important to be aware of these complications and need for careful pathologic examination of tissue removed for implant related complications to make the correct diagnosis for further patient management and treatment. It is important to be aware of this entity at this site as it can be easily misdiagnosed on histologic grounds and to exclude sarcomatoid carcinoma, malignant melanoma and pleomorphic sarcoma by an appropriate panel of immunostains to arrive at the correct diagnosis of ALCL.
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影响因子：
120.7
作者：
de Jong, Daphne;Vasmel, Wies L. E.;van Leeuwen, Flora E.
通讯作者：
van Leeuwen, Flora E.
影响因子：
1.3
作者：
Iyengar, P;Reid-Nicholson, M;Moreira, AL
通讯作者：
Moreira, AL
影响因子：
1.5
作者：
Olack, Brian;Gupta, Raavi;Brooks, Glen S.
通讯作者：
Brooks, Glen S.
影响因子：
3.7
作者：
Weldon, CB;Jaffe, BM;Kahn, MJ
通讯作者：
Kahn, MJ
影响因子：
3.5
作者：
Fritzsche, Florian Rudolf;Pahl, Stefan;Kristiansen, Glen
通讯作者：
Kristiansen, Glen