Non-gaussianity of low frequency heart rate variability and sympathetic activation: lack of increases in multiple system atrophy and Parkinson disease.
Non-gaussianity of low frequency heart rate variability and sympathetic activation: lack of increases in multiple system atrophy and Parkinson disease.
复制标题
DOI：
10.3389/fphys.2012.00034
复制
发表时间：
2012
影响因子：
4
通讯作者：
Yamamoto Y
中科院分区：
文献类型：
--
作者：
Kiyono K;Hayano J;Kwak S;Watanabe E;Yamamoto Y
自主神经系统的长期动态心率变异性（HRV）指标的相关性尚未完全了解。在这项研究中，我们评估了从日间（12：00-18：00）霍尔特记录获得的常规HRV指数，以及最近提出的非高斯指数（λ; Kiyono等人，）在12例多系统萎缩（MSA）和10例帕金森病（PD）患者中，已知有不同程度的心脏迷走神经和交感神经功能障碍。与年龄匹配的健康对照组相比，MSA患者显示HRV显著降低，最可能反映了迷走神经心率控制受损，但PD患者没有显示出这种降低的变异性。在MSA和PD患者中，反映交感迷走神经平衡的低频/高频（LF/HF）比值和短期分形指数α1均显著降低，与充血性心力衰竭（CHF）伴交感神经功能不全患者相同。相反，非高斯指数λ的分析表明，在CHF患者中观察到的间歇性和非高斯HRV的显著增加在MSA和PD交感功能障碍患者中未观察到。这些发现提供了额外的证据之间的关系的非高斯波动性的HRV和交感神经活动增加。
The correlates of indices of long-term ambulatory heart rate variability (HRV) of the autonomic nervous system have not been completely understood. In this study, we evaluated conventional HRV indices, obtained from the daytime (12:00–18:00) Holter recording, and a recently proposed non-Gaussianity index (λ; Kiyono et al.,) in 12 patients with multiple system atrophy (MSA) and 10 patients with Parkinson disease (PD), known to have varying degrees of cardiac vagal and sympathetic dysfunction. Compared with the age-matched healthy control group, the MSA patients showed significantly decreased HRV, most probably reflecting impaired vagal heart rate control, but the PD patients did not show such reduced variability. In both MSA and PD patients, the low-to-high frequency (LF/HF) ratio and the short-term fractal exponent α1, suggested to reflect the sympathovagal balance, were significantly decreased, as observed in congestive heart failure (CHF) patients with sympathetic overdrive. In contrast, the analysis of the non-Gaussianity index λ showed that a marked increase in intermittent and non-Gaussian HRV observed in the CHF patients was not observed in the MSA and PD patients with sympathetic dysfunction. These findings provide additional evidence for the relation between the non-Gaussian intermittency of HRV and increased sympathetic activity.
登录
查看更多内容
影响因子：
2.7
作者：
Kuriyama, N;Mizuno, T;Nakagawa, M
通讯作者：
Nakagawa, M
影响因子：
4
作者：
Hayano J;Kiyono K;Struzik ZR;Yamamoto Y;Watanabe E;Stein PK;Watkins LL;Blumenthal JA;Carney RM
通讯作者：
Carney RM
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
168.9
作者：
Bauer, Axel;Kantelhardt, Jan W.;Schmidt, Georg
通讯作者：
Schmidt, Georg
影响因子：
37.8
作者：
Bigger, JT;Steinman, RC;Cohen, RJ
通讯作者：
Cohen, RJ