Relation between nodule size and 18F-FDG-PET SUV for malignant and benign pulmonary nodules.
Relation between nodule size and 18F-FDG-PET SUV for malignant and benign pulmonary nodules.
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DOI：
10.1186/1756-8722-1-13
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发表时间：
2008-09-22
影响因子：
28.5
通讯作者：
Gona J
中科院分区：
文献类型：
--
作者：
Khalaf M;Abdel-Nabi H;Baker J;Shao Y;Lamonica D;Gona J
使用18F-FDG PET评估肺部病变的最常见半定量方法是FDG标准化摄取值（SUV）。2.5或更高的SUV临界值已用于区分良性和恶性结节。本研究的目的是探讨肺结节大小与SUV之间的相关性。回顾性分析，从420例转诊患者中选择了173例患者进行肺部病变评价。所有入选患者的CT和PET扫描和组织病理学活检均为阳性。恶性和良性结节的大小和SUVmax的散点图拟合线性回归方程。使用SUVmax临界值2.5创建点图以计算灵敏度、特异性和准确度。线性回归方程和（R2）s以及恶性和良性结节的趋势线表明，恶性结节的回归线的斜率大于良性结节。第1组（≤ 1.0 cm）的28个结节使用SUVmax临界值2.5绘制在点图中。敏感性、特异性和准确性分别为85%、36%和54%。同样，计算了SUVmax临界值为2.5时的敏感性、特异性和准确性，发现第2组的敏感性、特异性和准确性分别为91%、47%和79 Ocm）分别为94%、23%和76%;组4（> 3.0cm）分别为100%、17%和82%。点图的先前结果表明，使用SUVmax截止值2.5的测试的灵敏度和准确度随着肺结节直径的增加而增加。恶性结节的回归线斜率大于良性结节。尽管SUVmax临界值2.5在评价大肺结节（> 1.0 cm）时是一个有用的工具，但在评价小肺结节（≤ 1.0 cm）时没有价值或价值极小。
The most common semiquantitative method of evaluation of pulmonary lesions using 18F-FDG PET is FDG standardized uptake value (SUV). An SUV cutoff of 2.5 or greater has been used to differentiate between benign and malignant nodules. The goal of our study was to investigate the correlation between the size of pulmonary nodules and the SUV for benign as well as for malignant nodules. Retrospectively, 173 patients were selected from 420 referrals for evaluation of pulmonary lesions. All patients selected had a positive CT and PET scans and histopathology biopsy. A linear regression equation was fitted to a scatter plot of size and SUVmax for malignant and benign nodules together. A dot diagram was created to calculate the sensitivity, specificity, and accuracy using an SUVmax cutoff of 2.5. The linear regression equations and (R2)s as well as the trendlines for malignant and benign nodules demonstrated that the slope of the regression line is greater for malignant than for benign nodules. Twenty-eight nodules of group one (≤ 1.0 cm) are plotted in a dot diagram using an SUVmax cutoff of 2.5. The sensitivity, specificity, and accuracy were calculated to be 85%, 36% and 54% respectively. Similarly, sensitivity, specificity, and accuracy were calculated for an SUVmax cutoff of 2.5 and found to be 91%, 47%, and 79% respectively for group 2 (1.1–2.0 cm); 94%, 23%, and 76%, respectively for group 3 (2.1–3.0 cm); and 100%, 17%, and 82%,, respectively for group 4 (> 3.0 cm). The previous results of the dot diagram indicating that the sensitivity and the accuracy of the test using an SUVmax cutoff of 2.5 are increased with an increase in the diameter of pulmonary nodules. The slope of the regression line is greater for malignant than for benign nodules. Although, the SUVmax cutoff of 2.5 is a useful tool in the evaluation of large pulmonary nodules (> 1.0 cm), it has no or minimal value in the evaluation of small pulmonary nodules (≤ 1.0 cm).
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影响因子：
5.3
作者：
Nomori, H;Watanabe, K;Uno, K
通讯作者：
Uno, K
DOI：
10.1007/s00259-004-1552-7
发表时间：
2004-09-01
影响因子：
9.1
作者：
Herder, GJ;Golding, RP;Smit, EF
通讯作者：
Smit, EF
影响因子：
3.1
作者：
Tian, M;Zhang, H;Endo, K
通讯作者：
Endo, K
DOI：
10.1007/s00259-004-1706-7
发表时间：
2005-04-01
影响因子：
9.1
作者：
Buck, AK;Hetzel, M;Reske, SN
通讯作者：
Reske, SN
影响因子：
5.5
作者：
Lee, KS;Kim, Y;Primack, SL
通讯作者：
Primack, SL