Effects of growth hormone on the ontogenetic allometry of craniofacial bones.
Effects of growth hormone on the ontogenetic allometry of craniofacial bones.
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DOI：
10.1111/ede.12025
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发表时间：
2013-03
影响因子：
2.9
通讯作者：
Hallgrímsson B
中科院分区：
文献类型：
--
作者：
Gonzalez PN;Kristensen E;Morck DW;Boyd S;Hallgrímsson B
生物体的大小是由具有全身和局部效应的激素介导的遗传和环境因素之间的相互作用控制的。由于尺寸的变化通常不是等距的，因此通过个体发育异速生长模式的修改可以产生相当大的形状多样性。在这项研究中，我们评估了生长激素 (GH) 释放的时间和剂量对颅面骨生长和相关形状变化的作用。我们采用纵向研究设计，分析了在青春期前后开始补充 GH 的 GH 缺乏小鼠。我们获得了 21 至 60 天龄颅骨的 3D 体内显微 CT 图像，并使用几何形态测量学来分析对照小鼠以及 GH 缺乏治疗和未治疗小鼠的大小和形状变化。循环中生长激素的不同水平改变了成人头骨的大小和形状，并对颅底、颅顶和面部产生不同的影响。虽然颅底软骨病和面部缝合线容易受到 GH 补充的直接或间接影响，但其对拱顶的影响可以忽略不计。这种不同的反应支持骨骼成分的内在生长轨迹在控制系统因素引起的改变中的作用。与预期相反，GH 治疗的时机对追赶生长没有影响。 GH 水平还通过诱导其位置和形状空间延伸的变化来改变个体发育轨迹，这表明差异在 21 天之前出现，并且由于 GHD 组个体发育轨迹的截断而进一步加剧。
Organism size is controlled by interactions between genetic and environmental factors mediated by hormones with systemic and local effects. As changes in size are usually not isometric, a considerable diversity in shape can be generated through modifications in the patterns of ontogenetic allometry. In this study we evaluated the role of timing and dose of growth hormone (GH) release on growth and correlated shape changes in craniofacial bones. Using a longitudinal study design, we analyzed GH deficient mice treated with GH supplementation commencing pre- and post-puberty. We obtained 3D in vivo micro-CT images of the skull between 21 and 60 days of age and used geometric morphometrics to analyze size and shape changes among control and GH deficient treated and non-treated mice. The variable levels of circulating GH altered the size and shape of the adult skull, and influenced the cranial base, vault, and face differently. While cranial base synchondroses and facial sutures were susceptible to either the direct or indirect effect of GH supplementation, its effect was negligible on the vault. Such different responses support the role of intrinsic growth trajectories of skeletal components in controlling the modifications induced by systemic factors. Contrary to the expected, the timing of GH treatment did not have an effect on catch-up growth. GH levels also altered the ontogenetic trajectories by inducing changes in their location and extension in the shape space, indicating that differences arose before 21 days and were further accentuated by a truncation of the ontogenetic trajectories in GHD groups.
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影响因子：
3.3
作者：
Debat, V;Bégin, M;David, JR
通讯作者：
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通讯作者：
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作者：
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