Cardiac output versus pacing rate at rest and with exercise in dogs with AV block.
Cardiac output versus pacing rate at rest and with exercise in dogs with AV block.
复制标题
患有房室传导阻滞的狗在休息和运动时的心输出量与起搏率。
DOI：
10.1111/j.1540-8159.1988.tb04553.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Grote,LA
中科院分区：
文献类型：
--
作者：
Wessale,JL;Geddes,LA;Fearnot,NE;Janas,W;Grote,LA
To achieve maximum benefit from exercise (rate)‐responsive pacing in subjects with sinus node dysfunction and AV block, it is necessary to determine the pacing rate (HR) which produces maximum cardiac output (CO) under specified exercise conditions. However, the CO‐HR relationship for exercise has not been systematically investigated. To permit determination of the optimum HR, CO was measured at rest and with exercise for different pacing rates. Seven dogs with complete AV block and permanently implanted ventricular pacemakers were exercised on a treadmill for 5 min at each of our pacing rates (55, 76. 101, 116/min) and at two constant exercise levels (225 and 560 kg‐m/min). CO was determined by impedance cardiography during the resting state preceding exercise and during a brie/period (10–20 s) immediately after exercise, and was expressed as a percent of the CO determined at rest with HR ‐ 55/min. A three‐phase pattern of CO versus HH appears of exist for exercise as for rest. For exercise, starting from a low HR, CO increases markedly; a “plateau” is reached during which moderate increase in CO is achieved by increasing HR. At very rapid pacing rates, CO may actually decrease with further increase in HR. The results of this study suggest that a subject‐specific optimum HR exists for each constant exercise level. Moreover, the methodology employed in the study is applicable to the identification of optimum HR for any exercise (rate)‐responsive pacemaker.
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