Pattern formation in the Drosophila eye disc.
Pattern formation in the Drosophila eye disc.
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DOI：
10.1387/ijdb.072483jr
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Treisman JE
中科院分区：
文献类型：
--
作者：
Roignant JY;Treisman JE
果蝇复眼与眼成象盘的分化是一个渐进的过程：细胞列从后到前的顺序连续分化，细胞簇在每列内以规则的间隔形成，并且各个光感受器在每个簇内以定义的顺序分化。整个眼盘的分化进程是由分泌分子 Hedgehog 表达的正向自动调节环驱动的，该环路因第二个信号 Spitz 的插入而暂时延迟。 Hedgehog 通过诱导在不同范围内作用的次级信号来控制正负调节因子的表达，从而细化每列启动分化的空间位置。每列中的簇的位置由前一列中的簇分泌的抑制信号控制，并且通过Notch介导的侧向抑制在每个簇中挑选出单个创始神经元R8。然后，R8 通过产生短程信号 Spitz 依次招募周围细胞进行分化，从而诱导次级短程信号 Delta。内在转录因子与这两个信号结合作用，在小眼内产生细胞类型多样性。 Hedgehog 和 Spitz 信号沿着光感受器轴突传输，并在大脑内重新用作远程和局部线索，以触发目标神经元的分化和组装。
Differentiation of the Drosophila compound eye from the eye imaginal disc is a progressive process: columns of cells successively differentiate in a posterior to anterior sequence, clusters of cells form at regularly spaced intervals within each column, and individual photoreceptors differentiate in a defined order within each cluster. The progression of differentiation across the eye disc is driven by a positive autoregulatory loop of expression of the secreted molecule Hedgehog, which is temporally delayed by the intercalation of a second signal, Spitz. Hedgehog refines the spatial position at which each column initiates its differentiation by inducing secondary signals that act over different ranges to control the expression of positive and negative regulators. The position of clusters within each column is controlled by secreted inhibitory signals from clusters in the preceding column, and a single founder neuron, R8, is singled out within each cluster by Notch-mediated lateral inhibition. R8 then sequentially recruits surrounding cells to differentiate by producing a short-range signal, Spitz, which induces a secondary short-range signal, Delta. Intrinsic transcription factors act in combination with these two signals to produce cell-type diversity within the ommatidium. The Hedgehog and Spitz signals are transported along the photoreceptor axons and reused within the brain as long-range and local cues to trigger the differentiation and assembly of target neurons.
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影响因子：
10.5
作者：
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