Specific MiRNAs in naïve T cells associated with Hepatitis C Virus-induced Hepatocellular Carcinoma.
Specific MiRNAs in naïve T cells associated with Hepatitis C Virus-induced Hepatocellular Carcinoma.
复制标题
幼稚 T 细胞中与丙型肝炎病毒诱导的肝细胞癌相关的特定 miRNA
DOI：
10.7150/jca.49594
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
Mao J
中科院分区：
文献类型：
--
作者：
Yan P;Pang P;Hu X;Wang A;Zhang H;Ma Y;Zhang K;Ye Y;Zhou B;Mao J
肝细胞癌（HCC）是世界上第五大最常见的癌症类型，也是导致癌症相关死亡的第二大原因。丙型肝炎病毒（HCV）感染是肝纤维化和肝硬化的主要原因，这反过来又显著增加了发生HCC的风险。系统免疫反应在保护真核细胞免受外源抗原的侵害中起着至关重要的作用。在本研究中，为了确定hcv诱导的HCC （HCV-HCC）中T细胞和miRNA之间的关联，我们结合了来自HCV-HCC组织的大量mRNA和miRNA测序数据，以及来自T细胞的单细胞RNA测序（RNA-seq）数据。解卷积的大量RNA-seq数据和miRNA谱能够鉴定初始CD4+ T细胞相关的miRNA，这可能有助于阐明抗hcv免疫反应的潜在机制。利用大量RNA-seq数据，目前的分析提供了一种评估mirna与细胞成分之间关系的可行方法，为T细胞相关mirna在HCV-HCC中的作用提供了有价值的见解。
Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and the second leading cause of cancer-associated mortality worldwide. Hepatitis C virus (HCV) infection is the primary cause of hepatic fibrosis and cirrhosis, which in turn, notably increase the risk of developing HCC. The systematic immune response plays a vital role in protecting eukaryotic cells from exogenous antigens. In the present study, to determine the association between T cells and miRNAs in HCV-induced HCC (HCV-HCC), bulk mRNA and miRNA sequencing data from HCV-HCC tissues were combined, along with single-cell RNA sequencing (RNA-seq) data from T cells. Deconvoluted bulk RNA-seq data and miRNA profiles enabled the identification of naive CD4+ T cell-associated miRNAs, which may help to elucidate the underlying mechanism of the anti-HCV immune response. Using bulk RNA-seq data, the current analysis presents a feasible method for assessing the relationship between miRNAs and cell components, providing valuable insights into the effects of T cell-associated miRNAs in HCV-HCC.
登录
查看更多内容
影响因子：
5.8
作者：
Gu, Zuguang;Eils, Roland;Schlesner, Matthias
通讯作者：
Schlesner, Matthias
影响因子：
50.3
作者：
Hellmann MD;Callahan MK;Awad MM;Calvo E;Ascierto PA;Atmaca A;Rizvi NA;Hirsch FR;Selvaggi G;Szustakowski JD;Sasson A;Golhar R;Vitazka P;Chang H;Geese WJ;Antonia SJ
通讯作者：
Antonia SJ
影响因子：
3.6
作者：
Axley P;Ahmed Z;Ravi S;Singal AK
通讯作者：
Singal AK
DOI：
10.1038/s41577-019-0180-1
发表时间：
2019-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Goronzy JJ;Weyand CM
通讯作者：
Weyand CM
影响因子：
16.6
作者：
Karaayvaz M;Cristea S;Gillespie SM;Patel AP;Mylvaganam R;Luo CC;Specht MC;Bernstein BE;Michor F;Ellisen LW
通讯作者：
Ellisen LW