Attention-induced variance and noise correlation reduction in macaque V1 is mediated by NMDA receptors.
Attention-induced variance and noise correlation reduction in macaque V1 is mediated by NMDA receptors.
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DOI：
10.1016/j.neuron.2013.03.029
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发表时间：
2013-05-22
期刊：
影响因子：
16.2
通讯作者：
Thiele A
中科院分区：
文献类型：
--
作者：
Herrero JL;Gieselmann MA;Sanayei M;Thiele A
注意力通过影响神经元代码的不同方面来改善感知。它提高了放电率，降低了神经元的放电率变异性和噪声相关性，并改变了振荡活动的强度。注意诱导的纹状体皮质心率增强需要胆碱能机制。神经药理学机制负责注意诱导的方差和噪声相关性减少或那些支持振荡活动的变化是未知的。我们发现，离子型神经元能受体激活所需的注意力诱导的速率方差，噪声相关性，和LFP γ功率降低猕猴V1，但不是注意力诱导的速率调制。NMDA受体介导注意诱导的方差减少和注意诱导的噪声相关性减少。我们的研究结果表明，注意力通过多种机制改善感觉加工，这些机制在受体水平上是不可分离的。NMDA受体有助于方差和协方差的减少胆碱能和NMDA受体在注意调节中发挥不同的功能注意力影响V1神经元活动的二阶统计量NMDA和AMPA受体阻断剂相反地影响V1 γ频率振荡注意力通过增加反应强度和保真度来改善神经元的处理。Herrero等人表明NMDA受体的可用性是增加反应保真度所选择性需要的。这项研究在受体水平上分离了注意力机制。
Attention improves perception by affecting different aspects of the neuronal code. It enhances firing rates, it reduces firing rate variability and noise correlations of neurons, and it alters the strength of oscillatory activity. Attention-induced rate enhancement in striate cortex requires cholinergic mechanisms. The neuropharmacological mechanisms responsible for attention-induced variance and noise correlation reduction or those supporting changes in oscillatory activity are unknown. We show that ionotropic glutamatergic receptor activation is required for attention-induced rate variance, noise correlation, and LFP gamma power reduction in macaque V1, but not for attention-induced rate modulations. NMDA receptors mediate attention-induced variance reduction and attention-induced noise correlation reduction. Our results demonstrate that attention improves sensory processing by a variety of mechanisms that are dissociable at the receptor level. NMDA receptors aid variance and covariance reduction Cholinergic and NMDA receptors serve different functions in attentional modulation Attention affects second-order statistics of neuronal activity in V1 NMDA and AMPA receptor blockade oppositely affect V1 gamma frequency oscillations Attention improves neuronal processing by increasing response strength and fidelity. Herrero et al. show that NMDA receptor availability is selectively required for increased response fidelity. The study isolates attentional mechanisms at the receptor level.
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DOI：
10.1073/pnas.1011284108
发表时间：
2011-07-05
影响因子：
11.1
作者：
Buffalo, Elizabeth A.;Fries, Pascal;Desimone, Robert
通讯作者：
Desimone, Robert
影响因子：
64.8
作者：
Gutnisky, Diego A.;Dragoi, Valentin
通讯作者：
Dragoi, Valentin
影响因子：
64.8
作者：
Hupé, JM;James, AC;Bullier, J
通讯作者：
Bullier, J
影响因子：
16.2
作者：
Mitchell, Jude F.;Sundberg, Kristy A.;Reynolds, John H.
通讯作者：
Reynolds, John H.
DOI：
10.1126/science.1171402
发表时间：
2009-05-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gregoriou GG;Gotts SJ;Zhou H;Desimone R
通讯作者：
Desimone R