Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.
Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.
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DOI：
10.1371/journal.pone.0017213
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发表时间：
2011-02-18
期刊：
影响因子：
3.7
通讯作者：
Monagle P
中科院分区：
文献类型：
--
作者：
Ignjatovic V;Lai C;Summerhayes R;Mathesius U;Tawfilis S;Perugini MA;Monagle P
心血管疾病、血栓形成和癌症等重大疾病的发病率随着年龄的增长而增加，是全世界死亡的主要原因，新生儿和儿童在某种程度上免受这些老年疾病的影响。我们假设血浆蛋白存在主要的发育差异，这些差异有助于重大疾病发生率的年龄相关变化。我们使用2D-DIGE方法评估了健康新生儿、儿童和成人的人血浆蛋白质组。我们证明了多达100个蛋白质点的数量和丰度的显着变化，这些蛋白质点在从新生儿和儿童到成人的血浆蛋白质组过渡期间具有显着差异。已知这些蛋白质参与许多生理过程，例如铁转运和稳态、免疫应答、止血和凋亡等。重要的是，我们确定了随年龄差异表达的蛋白质与性别差异表达的蛋白质不同，并且血浆蛋白的磷酸化程度也随年龄变化。鉴于这些蛋白质在人体生理学中的多功能性，了解新生儿和儿童与成人相比血浆蛋白质组的差异将对我们理解人类发育生物学做出重大贡献。
The incidence of major diseases such as cardiovascular disease, thrombosis and cancer increases with age and is the major cause of mortality world-wide, with neonates and children somehow protected from such diseases of ageing. We hypothesized that there are major developmental differences in plasma proteins and that these contribute to age-related changes in the incidence of major diseases. We evaluated the human plasma proteome in healthy neonates, children and adults using the 2D-DIGE approach. We demonstrate significant changes in number and abundance of up to 100 protein spots that have marked differences in during the transition of the plasma proteome from neonate and child through to adult. These proteins are known to be involved in numerous physiological processes such as iron transport and homeostasis, immune response, haemostasis and apoptosis, amongst others. Importantly, we determined that the proteins that are differentially expressed with age are not the same proteins that are differentially expressed with gender and that the degree of phosphorylation of plasma proteins also changes with age. Given the multi-functionality of these proteins in human physiology, understanding the differences in the plasma proteome in neonates and children compared to adults will make a major contribution to our understanding of developmental biology in humans.
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