Tactile localization on digits and hand: structure and development.
Tactile localization on digits and hand: structure and development.
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DOI：
10.1177/0956797613478617
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发表时间：
2013-09
影响因子：
8.2
通讯作者：
Landau B
中科院分区：
文献类型：
--
作者：
Yoshioka T;Dillon MR;Beck GC;Rapp B;Landau B
手和手指的触觉刺激定位是体感知觉的基础。然而，人们对人类这种能力的发展或遗传基础知之甚少。我们研究了正常发育的儿童、青少年、成年人和患有威廉姆斯综合征（WS）的人的触觉定位，WS是一种导致广泛的严重视觉空间缺陷的遗传性疾病。正常发育的四岁儿童会犯很大的刺激定位错误，有时是跨手指的，但他们的错误揭示了手的结构内部表征。随着发育，错误呈指数级减少，在青春期达到成人水平。相比之下，患有WS的人无论年龄大小都表现出很大的定位错误和明显的交叉手指错误，这与正常的四岁儿童相似。因此，触觉定位反映了手的内部组织，甚至在正常发育的早期，在正常儿童中经历了实质性的发展，并且容易受到发育的影响，而不是遗传缺陷下的组织损伤。
Localization of tactile stimuli to the hand and digits is fundamental to somatosensory perception. However, little is known about the development or genetic bases of this ability in humans. We examined tactile localization in normally developing children, adolescents, adults, and people with Williams syndrome (WS), a genetic disorder resulting in a wide range of severe visual-spatial deficits. Normally developing four-year-olds made large stimulus localization errors, sometimes across digits, but nevertheless their errors revealed a structured internal representation of the hand. Errors became exponentially smaller over development, reaching adult level by adolescence. In contrast, people with WS showed large localization errors regardless of age and significant cross-digit errors, a profile similar to normal four-year-olds. Thus, tactile localization reflects internal organization of the hand even early in normal development, undergoes substantial development in normal children, and is susceptible to developmental, but not organizational impairment under genetic deficit.
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影响因子：
2.6
作者：
Hoffmann, JE;Landau, B;Pagani, B
通讯作者：
Pagani, B
影响因子：
1.5
作者：
Dykens, EM
通讯作者：
Dykens, EM
DOI：
10.1073/pnas.0704311104
发表时间：
2007-09-18
影响因子：
11.1
作者：
Marenco, Stefano;Siuta, Michael A.;Berman, Karen Faith
通讯作者：
Berman, Karen Faith
影响因子：
5.5
作者：
DARIANSMITH, I;KENINS, P
通讯作者：
KENINS, P
影响因子：
3.4
作者：
Landau, Barbara;Hoffman, James E.;Kurz, Nicole
通讯作者：
Kurz, Nicole